Evidence map›Paper›PMID 41951808›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Comparative longitudinal assessment of bone mineral density measured with radiofrequency echographic multi-spectrometry (REMS) and dual X-ray absorptiometry (DXA) in a cohort of peritoneal dialysis patients.

Mariana Diz Lopes, Angelo Fassio, Beatrice Bianco, Stefano Andreola, Matteo Apolloni, Francesco Pollastri, Davide Gatti, Maurizio Rossini, Andrea Spasiano, Pietro Manuel Ferraro and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Mariana Diz LopesSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy.
Angelo FassioSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy.
Beatrice BiancoSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Stefano AndreolaSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Matteo ApolloniSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy.
Francesco PollastriSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy.
Davide GattiSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy.
Maurizio RossiniSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy.
Andrea SpasianoSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Pietro Manuel FerraroSection of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Giovanni AdamiSection of Rheumatology, Department of Medicine, University of Verona, Verona, Italy. giovanni.adami@univr.it.ORCID http://orcid.org/0000-0002-8915-0755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a peritoneal dialysis longitudinal cohort, REMS and DXA showed similar bone density, but only DXA detected significant cortical bone loss. REMS tended to give lower bone mineral density values and did not correlate with DXA changes. REMS may complement DXA when DXA findings are difficult to interpret or when closer longitudinal monitoring is needed, but larger studies are needed to define its role.

backgroundDual X-ray absorptiometry (DXA) is the gold standard for bone mineral density (BMD) assessment in chronic kidney disease patients, but it can have limited accuracy and radiofrequency echographic multi-spectrometry (REMS) may overcome some of its limitations. We aimed to evaluate and compare longitudinal BMD changes assessed by DXA and REMS in peritoneal dialysis (PD) patients.

methodsProspective cohort study including 20 PD patients that underwent two separate DXA and REMS evaluations. Clinical, biochemical, and imaging data, including abdominal aorta calcification (AAC) scores and fracture history, were collected. Longitudinal BMD changes were analyzed using linear mixed-effects models.

resultsOver a median follow-up period of 19.8 months, DXA revealed significant BMD declines at the femoral neck (FN) (-3.2%, p = 0.039) while REMS showed non-significant numerical declines. REMS consistently yielded lower BMD values than DXA at both lumbar spine (LS) and FN. The trajectories of BMD over time were similar between DXA and REMS for LS (p = 0.806) and FN (p = 0.229), regardless of whether patients were receiving anti-osteoporosis treatment and of the presence of fractures. However, there was no correlation of the annualized changes in BMD at the FN and LS between the two methods (r

conclusionDXA detected a significant decline in BMD at cortical sites, whereas REMS did not, and the correlation of the annualized changes between the two methods in assessing changes over time was poor. Given the small sample size, larger studies are needed to clarify the comparative and possible complementary roles of REMS and DXA in monitoring bone health in end-stage kidney disease.

Indexed as

Bone DensityOsteoporosisPeritoneal DialysisAbsorptiometry, PhotonAdultAgedFemaleFemur NeckFollow-Up StudiesHumansKidney Failure, ChronicLongitudinal StudiesLumbar VertebraeMaleMiddle AgedProspective StudiesBone mineral densityChronic kidney diseaseDXAOsteoporosisPeritoneal dialysisREMS

Identifiers

PMID41951808
PMCPMC13676635

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