ArticleScientific reports2026
Exploration of brain function changes in the visual cortex of astigmatic subjects based on fNIRS.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The primary objective of this research is to explore changes in brain activity among astigmatism patients, employing functional near-infrared spectroscopy (fNIRS). A prospective cross-sectional study comprising 57 participants (99 eyes) was conducted and segmented into three distinct sections. In PART I, 24 participants (48 eyes) with astigmatism (Group A) and 18 participants (36 eyes) without astigmatism (Group B) were assessed using fNIRS to investigate the variations across different brain regions and channels. PART II involved 15 participants with monocular astigmatism (15 eyes), who received complete spherical optical correction, followed by fNIRS assessments after visual stimulation using E-Prime software. The study examined the activation levels of the occipital visual cortex and the functional connectivity strength of the brain, comparing these metrics pre- and post-cylindrical correction. PART III: Following the correction of the initial refractive error in Group A, + 2.00 diopter cylinder (DC) lenses were employed to induce astigmatism at various axes. These axes were categorized into three groups: oblique astigmatism group, with-the-rule astigmatism (WTR), and against-the-rule astigmatism (ATR). fNIRS was conducted during task performance to assess the strength and activation level of brain functional connectivity across different astigmatism axes of the same diopter. PART I: The functional connectivity strength of HbO PART II: Significant differences in the β values of the left and right visual cortex were detected in cases of monocular astigmatism before and after astigmatism correction. (P = 0.002 and P = 0.004). The functional connectivity strength in the post-cylindrical correction condition exceeded that in the pre-cylindrical correction condition; nevertheless, this variation did not attain statistical significance (P > 0.05). PART III: The functional connectivity strength and activation level of the HbO
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