Evidence map›Paper›PMID 41951613›Full record

ArticleNature communications2026

A principled basis for nonequilibrium network flows.

Ying-Jen Yang, Ken A Dill

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ying-Jen YangLaufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY, USA. ying-jen.yang@stonybrook.edu.ORCID http://orcid.org/0000-0002-2559-2773
Ken A DillLaufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2390-2002

Funding

John Templeton Foundation (JTF) 62564U.S. Department of Health & Human Services | National Institutes of Health (NIH) RM1-GM135136
6 · The paper itself

Abstract

The great power of equilibrium statistical physics comes from its principled foundations: its First Law (conservation), Second Law (variational tendency principle), and its Legendre Transforms from observables (U, V, N) to their driving forces (T, p, μ). Here, we generalize this structure to nonequilibria in Caliber Force Theory, replacing state entropies with path entropies; and replacing (U, V, N) with dynamic observables (node probabilities, edge traffics, and cycle fluxes). Caliber Force Theory derives dynamical forces and a complete set of conjugate relations: (i) It yields generalized Maxwell-Onsager relations and fluctuation-response relations, applicable far from equilibrium; (ii) It constructs dynamical models from mixed force-observable constraints; and (iii) It reveals relationships-including a generalized Einstein relation, an "equal-traffic" rule for optimizing molecular motors, and a "third Kirchhoff's law" of stochastic transport-and can resolve some dynamical paradoxes.

Identifiers

PMID41951613
PMCPMC13237033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.