Evidence map›Paper›PMID 41951611›Full record

ArticleNature communications2026

CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic.

Thomas J Kelly, Xiaojie Liu, Yao Huang, Ying Hu, Vladislav Friedman, Cecilia J Hillard, Qing-Song Liu

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas J KellyDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA. tjkelly@mcw.edu.ORCID http://orcid.org/0000-0002-8390-0818
Xiaojie LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-9843-1674
Yao HuangDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0009-0007-5733-3112
Ying HuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
Vladislav FriedmanDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-5567-2520
Cecilia J HillardDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-9678-748X
Qing-Song LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA. qsliu@mcw.edu.ORCID http://orcid.org/0000-0003-1858-1504

Funding

Mechanistic studies of phosphodiesterase inhibitors in cocaine addictionR01DA035217 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI LIU, QING-SONG · 2014 to 2023
$3.4M
Circuit-specific actions of endocannabinoids in stress and mood disordersR01MH121454 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J, LIU, QING-SONG · 2019 to 2023
$1.9M
Medical Scientist Training ProgramT32GM154638 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI Joseph T Barbieri, Nita H Salzman · 2025 to 2026
$1.8M
The role of midbrain mTOR signaling in hyperactivity and impulsivityR01MH140483 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI Qing-song Liu, John R Mantsch · 2026 to 2026
$521k
NIGMS NIH HHS T32 GM154638U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH121454U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH140483U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA035217
6 · The paper itself

Abstract

Cannabinoids, such as Δ

Indexed as

AnxietyCorpus StriatumGyrus CinguliReceptor, Cannabinoid, CB1AnimalsBehavior, AnimalDronabinolEndocannabinoidsMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsSignal TransductionDronabinolEndocannabinoidsReceptor, Cannabinoid, CB1

Identifiers

PMID41951611
PMCPMC13237297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.