ArticleNature communications2026
Occlusion-activated autonomous piezoelectric implants for adaptive prevention of peri-implantitis.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Piezoelectric Nanocoatings on Bio-Interfaces: Microenvironment Remodeling, Biofilm Disruption, and Immunomodulatory Integration.Microorganisms · 2026Review
- From Static Scaffolds to Responsive Implants: 3D-Printed Field-Active Bioceramics for Adaptive Bone Regeneration.Advanced healthcare materials · 2026Review
- Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants.Materials today. Bio · 2026Article
- Piezoelectric scaffolds for bone regeneration: a systematic review of preclinical studies.Frontiers in bioengineering and biotechnology · 2026Review
- Piezoelectric materials for surface modification of titanium-based implants: material design, biological mechanisms, and translational challenges.Frontiers in bioengineering and biotechnology · 2026Review
- Harnessing ultrasound-responsive technologies for precision periodontitis therapy: a perspective.Theranostics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
More than one-third of the global population suffers from dental defects, with osseointegrated implants being the gold-standard intervention; yet, their long-term functional performance is hindered by peri-implantitis. Here, we present an autonomous piezoelectric implant that delivers adaptive antibacterial and anti-inflammatory functionalities through physiological occlusal activation without any external intervention. The implant demonstrates good functional durability, sustaining consistent bioelectric outputs through over 1,000,000 loading-unloading cycles and exhibiting stable electrical performance in simulated physiological environments for over 30 days. Besides, integration with machine learning enables reliable, patient-specific prediction and real-time modulation of occlusal mechano-adaptive voltage responses. The autonomous implant achieves tri-modal therapeutic integration: (ⅰ) electrocatalytic bactericidal activity via controlled reactive oxygen species generation, (ⅱ) electrically induced immunomodulation of macrophages from pro- to anti-inflammatory phenotypes, and (ⅲ) electrostimulation-enhanced osteogenesis surpassing conventional titanium alloys, both in vitro and in vivo. These findings provide insights for occlusion-activated effective peri-implantitis intervention and a widely applicable strategy for developing autonomous and adaptable bioelectronic platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.