Evidence map›Paper›PMID 41951588›Full record

ArticleNature communications2026

PD-1 antibody-bound progenitor-exhausted CD8

Yohei Nose, Yoshiaki Yasumizu, Takuro Saito, Yamami Nakamura, Koichi Jinushi, Kaoru Fujikawa, Kota Momose, Kotaro Yamashita, Koji Tanaka, Kazuyoshi Yamamoto and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yohei Nose *Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0003-1973-9035
Yoshiaki Yasumizu *Experimental Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-9872-4909
Takuro SaitoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan. tsaito@gesurg.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-1733-5064
Yamami NakamuraExperimental Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.
Koichi JinushiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Kaoru FujikawaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Kota MomoseDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Kotaro YamashitaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Koji TanakaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Kazuyoshi YamamotoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-7645-2412
Tomoki MakinoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0001-7918-4217
Tsuyoshi TakahashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0003-2397-1478
Azumi UeyamaDepartment of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Yukinori KurokawaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-2883-0132
Eiichi SatoDepartment of Pathology, Institute of Medical Science (Medical Research Center), Tokyo Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0060-7764
Naganari OhkuraExperimental Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.
Shimon SakaguchiExperimental Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0001-8265-6094
Hisashi WadaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.ORCID http://orcid.org/0000-0002-5444-6193
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 20K17685MEXT | Japan Society for the Promotion of Science (JSPS) 23K08194MEXT | Japan Society for the Promotion of Science (JSPS) 23K15472
6 · The paper itself

Abstract

While progenitor-exhausted T cells (Tpex) expressing TCF1 and PD-1 are crucial for the therapeutic effect of immune checkpoint inhibitors (ICIs) with therapeutic anti-PD-1 antibodies (aPD-1), the dynamics of ICI-bound Tpex are not fully understood. In this study, we investigate ICI-bound T cells in detail using combined sequencing analysis at the single-cell level. By analyzing samples from gastrointestinal cancer patients with or without ICI treatment, we find that Tpex are enriched in proximal lymph nodes (LNs) and proliferate at a high rate after ICI treatment. Importantly, aPD-1 high-bound Tpex in LNs share T-cell receptor clonotypes with intratumoral exhausted CD8

Indexed as

CD8-Positive T-LymphocytesGastrointestinal NeoplasmsImmune Checkpoint InhibitorsLymph NodesProgrammed Cell Death 1 ReceptorAnimalsFemaleHepatocyte Nuclear Factor 1-alphaHumansLymphocytes, Tumor-InfiltratingT-Cell ExhaustionHepatocyte Nuclear Factor 1-alphaImmune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID41951588
PMCPMC13237225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.