Evidence map›Paper›PMID 41951399›Full record

ArticleEndocrine journal2026

Early predictors of 6-month thyroid-stimulating antibody levels after radioactive iodine therapy for Graves' disease: implications for pregnancy planning.

Seigo Tachibana, Yuji Nagayama, Takashi Fukuda, Yusuke Taguchi, Daisuke Tatsushima, Yusuke Mori, Hisakazu Shindo, Hiroshi Takahashi, Shinya Sato, Hiroyuki Yamashita

Abstract read
In one paragraph

Article in Endocrine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seigo TachibanaDepartment of Endocrinology, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0000-0003-4154-500X
Yuji NagayamaDepartment of Endocrinology, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0000-0002-5058-9349
Takashi FukudaDepartment of Endocrinology, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0009-0007-5846-8748
Yusuke TaguchiDepartment of Endocrinology, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0009-0001-3570-3561
Daisuke TatsushimaDepartment of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0000-0001-9802-3697
Yusuke MoriDepartment of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0009-0003-4297-134X
Hisakazu ShindoDepartment of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0000-0002-1424-620X
Hiroshi TakahashiDepartment of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0009-0005-0410-1399
Shinya SatoDepartment of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0000-0002-0761-6209
Hiroyuki YamashitaDepartment of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.ORCID http://orcid.org/0009-0001-0805-8886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current guidelines recommend a 6-month contraception period following radioactive iodine therapy (RAIT) for Graves' disease (GD), based primarily on radiation safety considerations; however, they do not account for the post-treatment surge in thyroid-stimulating antibodies (TSAb), which poses risks for fetal and neonatal GD. This retrospective study aimed to identify factors influencing TSAb trajectories and construct a predictive model for TSAb levels at 6 months after RAIT. We analyzed 82 patients who underwent RAIT, with TSAb values standardized to the upper limit of normal (ULN) to account for different assay methods. Multivariable linear regression identified the duration of antithyroid drug and potassium iodide administration, pre-RAIT TSAb levels, changes in TSAb at 3 months (3M), fractional reduction in TW at 3M, and assay method as significant predictors of TSAb levels at 6 months (adjusted R

Indexed as

Graves DiseaseImmunoglobulins, Thyroid-StimulatingIodine RadioisotopesAdultAntithyroid AgentsFemaleHumansPregnancyRetrospective StudiesAntithyroid AgentsImmunoglobulins, Thyroid-StimulatingIodine RadioisotopesContraceptionGraves’ diseaseRadioactive iodine therapyThyroid-stimulating antibody

Identifiers

PMID41951399
PMCPMC13378843

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.