Evidence map›Paper›PMID 41951260›Full record

ArticleBMJ open2026

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Jules P J Douwes, Annemijn L Tops, Petra Dibbets-Schneider, Berit M Verbist, Constanza A Fuentealba Bassaletti, Jeroen C Jansen, Kim S Koetsier, Victor S van Dam, Radboud W Koot, Floris H P van Velden and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05685836 (89Zr-Bevacizumab PET/CT Imaging of Vestibular Schwannomas for the Prediction of Bevacizumab Treatment Effect in Patients With Symptomatic Neurofibromatosis Type 2), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05685836 unknown statusnot on this map

89Zr-Bevacizumab PET/CT Imaging of Vestibular Schwannomas for the Prediction of Bevacizumab Treatment Effect in Patients With Symptomatic Neurofibromatosis Type 2

TypeobservationalSponsorLeiden University Medical CenterRan2022 to 2024Enrolled15ConditionsNeurofibromatosis 2ArmsBevacizumab Zirconium Zr-89
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jules P J DouwesDepartment of Otorhinolaryngology-Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands j.p.j.douwes@lumc.nl.ORCID http://orcid.org/0000-0002-8232-576X
Annemijn L TopsDepartment of Otorhinolaryngology-Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Petra Dibbets-SchneiderDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Berit M VerbistDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Constanza A Fuentealba BassalettiDepartment of Otorhinolaryngology-Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Jeroen C JansenDepartment of Otorhinolaryngology-Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Kim S KoetsierDepartment of Otorhinolaryngology-Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Victor S van DamDepartment of Otorhinolaryngology-Head and Neck Surgery, Erasmus MC, Rotterdam, The Netherlands.
Radboud W KootDepartment of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.
Floris H P van VeldenDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Martin PoolDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
Daniëlle VugtsDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Josefine E SchopmanDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Jelle J GoemanDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Lioe-Fee De Geus-OeiDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Erik F HensenDepartment of Otorhinolaryngology-Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Hans GelderblomDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTreatment with bevacizumab achieves both tumour stabilisation or regression and preservation or improvement of hearing. However, the efficacy of bevacizumab varies between patients and within patients. Side effects due to bevacizumab treatment are also common. It would be of value to predict therapeutic response prior to initiating therapy to prevent unnecessary exposure in patients unlikely to benefit. METHODS AND ANALYSIS: We aim to recruit 25 patients with ETHICS AND DISSEMINATION: This study was submitted via the Clinical Trials Information System reviewed and approved by the Medical Research Ethics Committee Leiden-The Hague-Delft Delft. The study findings will be disseminated through publication in peer-reviewed scientific journals and by presentation at national and international conferences. TRIAL REGISTRATION NUMBER: The trial is registered at ClinicalTrials.gov Protocol Registration and Results System under the registration ID: NCT05685836.

Indexed as

Antineoplastic Agents, ImmunologicalBevacizumabNeurilemmomaNeurofibromatosesNeuroma, AcousticPositron Emission Tomography Computed TomographySkin NeoplasmsAdultClinical Trials, Phase II as TopicFeasibility StudiesFemaleHumansMaleMiddle AgedNeurofibromatosis 2Prospective StudiesAntineoplastic Agents, ImmunologicalBevacizumabRadioisotopesNeuroradiologyNEUROSURGERYNUCLEAR MEDICINEONCOLOGYOTOLARYNGOLOGY

Identifiers

PMID41951260
PMCPMC13064135

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.