Evidence map›Paper›PMID 41950927›Full record

ArticleCell reports. Medicine2026

Preclinical evaluation of an mRNA vaccine developed from the first human isolate of bovine H5N1.

Hongli Li, Mengting Huang, Simin Feng, Wansheng Li, Dandan Wei, Xuechun Li, Yun Quan, Hao Gu, Ting Jiang, Yan Liu and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Hongli LiGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Mengting HuangGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Simin FengGuangzhou National Laboratory, Guangzhou 510000, China; Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China; Hubei Jiangxia Laboratory, Wuhan, Hubei 430207, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wansheng LiGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Dandan WeiNational Avian Influenza Para-Reference Laboratory (Guangzhou), Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Xuechun LiState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China.
Yun QuanGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Hao GuZhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; Shanghai RNACure Biopharma Co., Ltd., Shanghai 200438, China.
Ting JiangZhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; Shanghai RNACure Biopharma Co., Ltd., Shanghai 200438, China.
Yan LiuZhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; Shanghai RNACure Biopharma Co., Ltd., Shanghai 200438, China.
Jing LuZhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; Shanghai RNACure Biopharma Co., Ltd., Shanghai 200438, China.
Wenjun SongGuangzhou National Laboratory, Guangzhou 510000, China.
Xinkui ZhangNational Avian Influenza Para-Reference Laboratory (Guangzhou), Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Yujia YangNational Avian Influenza Para-Reference Laboratory (Guangzhou), Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Qianyu PanGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
LinLei ChenState Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China; Department of Microbiology, Queen Mary Hospital, Hong Kong 999077, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong 999077, China.
Jingyou YuGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Hantao LouState Key Laboratory of Medicinal Chemical Biology, Institute of Immunology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Mengyi ZhangInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650031, China.
Youchun WangInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650031, China.
Kelvin Kai-Wang ToState Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China; Department of Microbiology, Queen Mary Hospital, Hong Kong 999077, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong 999077, China.
Weixin JiaNational Avian Influenza Para-Reference Laboratory (Guangzhou), Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: jiaweixin@scau.edu.cn.
Jinzhong LinState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China. Electronic address: linjinzhong@fudan.edu.cn.
Qiong ZhangGuangzhou National Laboratory, Guangzhou 510000, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China. Electronic address: zhang_qiong2@gzlab.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the global threat posed by H5N1 clade 2.3.4.4b avian influenza, rapid development of effective vaccines is imperative. We design an mRNA vaccine encoding hemagglutinin (HA) from A/Texas/37/2024, the first bovine-to-human strain. In murine models, both wild-type and cleavage-site-modified HA vaccines elicit robust and durable humoral immunity, along with a balanced Th1/Th2 response, conferring complete protection against lethal homologous viral challenge. The vaccine, along with the World Health Organization (WHO)-recommended candidate (A/Astrakhan/3212/2020), elicits cross-clade binding antibody responses and demonstrates improvement against specific clades at a 1 μg dose. Pre-existing H1 immunity does not diminish H5-specific immunogenicity. In avian species, the vaccine also provides full protection against lethal clades (2.3.4.4b and 2.3.4.4h). Formulated with another ionizable lipid, the vaccine elicits responses comparable to benchmark lipid nanoparticles (LNPs) and shows a favorable safety profile in rats. This work establishes a rapidly adaptable mRNA-LNP vaccine prototype for pandemic preparedness against evolving avian influenza threats.

Indexed as

Influenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza VaccinesmRNA VaccinesRNA, MessengerAnimalsAntibodies, ViralCattleFemaleHemagglutinin Glycoproteins, Influenza VirusHumansMiceMice, Inbred BALB CRatsAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesmRNA VaccinesRNA, Messengerbovine H5N1clade 2.3.4.4bcross-clade protectionH5N1 mRNA vaccineionizable lipid

Identifiers

PMID41950927
PMCPMC13130686

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.