Associations of Elevated Red Cell Distribution Width (RDW) with Decreased Physical and Cognitive Function in Older Adults, and The Potential Mediation by Mitochondrial Energetics: The Study of Muscle, Mobility and Aging (SOMMA).

Kyoung Min Kim, Li-Yung Lui, Theresa Mau, Paul M Coen, Steven R Cummings

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Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Kyoung Min KimDivision of Endocrinology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.

Li-Yung LuiSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.

Theresa MauSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.

Paul M CoenAdventHealth, Translational Research Institute, Orlando, Florida, USA.

Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed the association between RDW and skeletal muscle mitochondrial energetics and how skeletal muscle mitochondrial energetics may mediate the associations of RDW with physical and cognitive performance. The study analyzed cross-sectional baseline data from the Study of Muscle, Mobility and Aging (SOMMA) that enrolled 864 participants aged 70 and older (mean=76.3 years). RDW, clinical and demographic parameters were assessed. Comprehensive evaluations were conducted for both physical and cognitive function using objective and subjective measures. Elevated RDW values were significantly correlated with decreased physical performance, evidenced by reduced cardiorespiratory fitness (VO

Indexed as

AgingCognitionErythrocyte IndicesMitochondriaMitochondria, MuscleAgedAged, 80 and overCardiorespiratory FitnessCross-Sectional StudiesEnergy MetabolismFemaleHumansMaleMuscle, SkeletalOxygen Consumption

Identifiers

PMID41950902

DOI10.14336/AD.2024.1724

PMCPMC13061556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.