Evidence map›Paper›PMID 41950470›Full record

ArticleJournal of the American Chemical Society2026

Optimized Xanthenium Photocages with Fused Ring Systems for Photoactivated Chemotherapy and G Protein-Coupled Receptor Photopharmacology.

Tibor Á Molnár, Eszter Kozma, Anna Benedikti, Márk Holczer, Attila Kormos, Zsombor Gonda, Ákos Balde, Selina Pühringer, Verena Handl, Christian Bayer and 5 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tibor Á MolnárMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Eszter KozmaMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.ORCID 0009-0009-2447-7683
Anna BenediktiMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Márk HolczerMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Attila KormosMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Zsombor GondaMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Ákos BaldeMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Selina PühringerGottfried Schatz Research Center─Division of Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria.
Verena HandlGottfried Schatz Research Center─Division of Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria.
Christian BayerGottfried Schatz Research Center─Division of Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria.
Waltraud HuberOtto Loewi Research Center─Division of Immunology, Research Unit CAM Lab, Medical University of Graz, 8010 Graz, Austria.
Nassim Ghaffari-Tabrizi-WizsyOtto Loewi Research Center─Division of Immunology, Research Unit CAM Lab, Medical University of Graz, 8010 Graz, Austria.
Linda WaldherrGottfried Schatz Research Center─Division of Medical Physics and Biophysics, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-9817-1358
Krisztina NémethMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.
Márton BojtárMTA─HUN-REN TTK Lendület "Momentum" Chemical Biology Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences. Magyar Tudósok Krt. 2, H-1117 Budapest, Hungary.ORCID 0000-0001-8459-4659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photocages are light-responsive chemical protecting groups that enable the controlled release of bioactive molecules. As the need for precise spatiotemporal manipulation in increasingly complex systems continues to grow, the development of novel photocage scaffolds remains essential. Herein, we show how the structural and electronic properties of xanthenium photocages determine their ground state stability. Based on rational design, we introduce their next generation built on the julolidine auxochrome, resulting in ultra efficient, green to red light activatable photocages,

Indexed as

Antineoplastic AgentsProdrugsReceptors, G-Protein-CoupledAnimalsHumansLightMolecular StructurePhotochemical ProcessesAntineoplastic AgentsProdrugsReceptors, G-Protein-Coupled

Identifiers

PMID41950470
PMCPMC13107459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.