Evidence map›Paper›PMID 41950320›Full record

ArticleScience advances2026

From vibrations to function: Spectroscopic detection and quantification of π-π stacking in drug-responsive protein complexes.

Narangerel Altangerel, Esther J Ocola, Benjamin W Neuman, Vladislav V Yakovlev, Syuan-Ting Kuo, Veerabhadra Reddy Vulupala, Kaustav Khatua, Hanyuan Zhang, Xin Yan, David H Russell and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Narangerel AltangerelTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-1617-3427
Esther J OcolaTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2845-283X
Benjamin W NeumanTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-1240-8954
Vladislav V YakovlevTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-4557-1013
Syuan-Ting KuoTexas A&M University, College Station, TX 77843, USA.
Veerabhadra Reddy VulupalaTexas A&M University, College Station, TX 77843, USA.
Kaustav KhatuaTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2497-3187
Hanyuan ZhangTexas A&M University, College Station, TX 77843, USA.ORCID 0009-0003-7973-0347
Xin YanTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-8292-130X
David H RussellTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-0830-3914
Shiqing XuTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0001-6260-9290
Carol A FierkeBrandeis University, Waltham, MA 02453, USA.ORCID 0000-0002-1481-0579
Wenshe Ray LiuTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-7078-6534
Alexei V SokolovTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-6879-7840
Philip R HemmerTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-2054-5318
Marlan O ScullyTexas A&M University, College Station, TX 77843, USA.ORCID 0000-0001-6397-4927

Funding

Use of the Noncanonical Amino Acid Mutagenesis Technique in Combination with Other Approaches to Study Functions of Posttranslational Lysine Modifications in ProteinsR35GM145351 · NIGMS · TEXAS A&M UNIVERSITY · PI Wenshe Ray Liu · 2022 to 2026
$2.6M
NIGMS NIH HHS R35 GM145351
6 · The paper itself

Abstract

Aromatic π-π stacking interactions are fundamental to protein architecture, molecular recognition, and drug efficacy, yet directly quantifying them under near-physiological conditions has remained challenging. Here, we use a recently developed spectroscopic platform, thermostable Raman interaction profiling (TRIP), that enables direct, label-free detection and quantification of aromatic π-π interactions in complex protein environments. Using the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) main protease (M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesProtease InhibitorsSARS-CoV-2COVID-19 Drug TreatmentHumansModels, MolecularPhenylalanineProtein MultimerizationSpectrum Analysis, RamanVibration3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesPhenylalanineProtease Inhibitors

Identifiers

PMID41950320
PMCPMC13154015

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.