Evidence map›Paper›PMID 41950227›Full record

ReviewEnvironmental science & technology2026

Persistence Assessment of Chemicals: Trajectories toward New Approach Methodologies (P-NAMs).

Kathrin Fenner, Daniel Zahn, Ulrich Jöhncke, Gabriel Sigmund, Philipp Mayer, Christopher Hughes, Hans Peter H Arp, Russell J Davenport, Anu Kapanen, Thorsten Reemtsma

Abstract readReview
In one paragraph

Review in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kathrin FennerEawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf 8600, Switzerland.ORCID 0000-0001-6068-8220
Daniel ZahnHelmholtz Centre for Environmental Research - UFZ, Department of Environmental Analytical Chemistry, Leipzig 04318, Germany.ORCID 0000-0003-3038-9371
Ulrich JöhnckeGerman Environment Agency, Section IV 2.3 Chemicals, Dessau-Roßlau 06844, Germany.
Gabriel SigmundEnvironmental Technology, Wageningen University, Wageningen 6700 AA, Netherlands.ORCID 0000-0003-2068-0878
Philipp MayerDepartment of Environmental and Resource Engineering, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID 0000-0001-5138-7506
Christopher HughesEmbark Chemical Consulting Ltd, Chester, CH2 1LR, U.K.ORCID 0000-0002-3298-9402
Hans Peter H ArpNorwegian Geotechnical Institute (NGI), Oslo 0484, Norway.ORCID 0000-0002-0747-8838
Russell J DavenportSchool of Engineering, Newcastle University, Newcastle Upon Tyne, NE1 7RU, U.K.
Anu KapanenEuropean Chemicals Agency, Helsinki 00121, Finland.
Thorsten ReemtsmaHelmholtz Centre for Environmental Research - UFZ, Department of Environmental Analytical Chemistry, Leipzig 04318, Germany.ORCID 0000-0003-1606-0764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical persistence has long been recognized as a critical determinant of ecosystem and human exposure, exemplified by legacy pollutants such as DDT, PCBs, and, more recently, PFAS. Despite decades of regulation and research, robust experimental half-life data are available for only a fraction of chemicals in use, hampering their persistence assessment. Current testing frameworks, while refined, lack the efficacy to address these large data gaps, underscoring the need for innovative approaches. We argue that new approach methodologies for persistence assessment (P-NAMs)─including high-throughput (HT) experimental systems and advanced

Indexed as

Environmental MonitoringEnvironmental PollutantsEnvironmental Pollutantsbiodegradation kineticsbiodegradation modelshigh-throughput testingREACHready biodegradabilitysimulation studiestransformation products

Identifiers

PMID41950227
PMCPMC13104176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.