ArticleProceedings of the National Academy of Sciences of the United States of America2026
Alternative microexon splicing code for a four-amino acid peptide of PTPRD governs behavioral development.
Ayako Imai, Hironori Izumi, Nagomi Ito, Hina Ogiso, Yuki Kitajima, Shuhei Kawase, Mizuki Sendo, Kenji Azechi, Toshihide Tabata, Yumie Koshidaka and 4 more
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In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
Ayako ImaiDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0009-0006-4969-0462 Hironori IzumiDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0009-0007-7580-1987 Nagomi ItoDepartment of Molecular Neuroscience, Interdisciplinary Graduate School of Medicine, Pharmacy, Sciences and Engineering, University of Toyama, Toyama 930-0194, Japan.ORCID 0009-0004-0298-4565 Hina OgisoDepartment of Biofunctional Molecular Chemistry, Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan.ORCID 0009-0001-0005-5496 Yuki KitajimaDepartment of Biological Information Processing, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan.
Shuhei KawaseDepartment of Biological Information Processing, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan.
Mizuki SendoDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Kenji AzechiDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0003-0696-2326 Toshihide TabataDepartment of Biological Information Processing, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan.ORCID 0000-0001-6158-647X Yumie KoshidakaLife Science Research Center, University of Toyama, Toyama 930-0194, Japan.
Shuya FukaiDepartment of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0002-1241-1443 Keizo TakaoResearch Center for Idling Brain Science, University of Toyama, Toyama 930-0194, Japan.
Hisashi MoriDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-9743-2456 Tomoyuki YoshidaDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-8476-3798 Funding
MEXT | Japan Society for the Promotion of Science (JSPS) JP20H03350MEXT | Japan Society for the Promotion of Science (JSPS) JP20K21444MEXT | Japan Society for the Promotion of Science (JSPS) JP21H00190MEXT | Japan Society for the Promotion of Science (JSPS) JP22H04922MEXT | Japan Society for the Promotion of Science (JSPS) JP23K18151MEXT | Japan Society for the Promotion of Science (JSPS) JP23K27276
6 · The paper itselfAbstract
Microexons of 3 to 27 nucleotides selectively regulated in the vertebrate nervous system have attracted attention as new elements for modifying the function of neuronal proteins. Protein tyrosine phosphatase δ (PTPRD) is one of presynaptic hubs for neuronal synaptic organization. Alternative splicing (AS) of three microexons, meA3, meA6, and meB, encoding 3, 6, and 4 amino acid-peptides, respectively, imparts structural diversity to PTPRD, due to which the resulting eight splice variants exhibit distinct synaptogenic properties. However, the regulatory mechanisms of AS and physiological significance of the AS code for
Indexed as
Alternative SplicingBehavior, AnimalExonsPeptidesReceptor-Like Protein Tyrosine Phosphatases, Class 2AnimalsBrainIntronsMiceNeuronsPeptidesReceptor-Like Protein Tyrosine Phosphatases, Class 2alternative splicingbehaviormicroexonPTPRDsynapse organizer
Identifiers
PMID41950098
PMCPMC13080001
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