Evidence map›Paper›PMID 41949989›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Home-based sleep monitoring reveals associations between amyloid accumulation and sleep alterations in individuals with subjective and mild cognitive impairment.

Antonia Buchal, Verena Dzialas, Elena Doering, Kathrin Giehl, Gérard N Bischof, David Elmenhorst, Thilo van Eimeren, Alexander Drzezga, Merle C Hoenig, T‐POT study group

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Foods (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antonia BuchalDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Verena DzialasDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Elena DoeringDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Kathrin GiehlDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Gérard N BischofDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
David ElmenhorstDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Thilo van EimerenDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Alexander DrzezgaDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Merle C HoenigDepartment of Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID 0000-0002-0831-750X
T‐POT study group

Funding

Alzheimer Forschung Initiative p21059Deutsche Forschungsgemeinschaft DR 445/9-1
6 · The paper itself

Abstract

introductionSleep disturbances have been associated with Alzheimer's disease (AD), but their relevance in preclinical stages, such as subjective cognitive decline (SCD), and their relationship with brain pathology remain unclear.

methodsWe used a portable sleep-monitoring headband over four consecutive nights to assess sleep in 19 cognitively unimpaired (CU), 15 SCD, and 20 mild cognitive impairment (MCI) participants with available amyloid positron emission tomography (PET). Linear-mixed-effects models compared sleep parameters across groups, accounting for amyloid burden, age, sex, education, and recording. Regional and voxel-wise analyses examined regional associations between sleep parameters and amyloid burden.

resultsMCI patients presented reduced N3 (i.e., deep sleep), while SCD individuals showed longer N1 (i.e., light sleep) duration compared to CU. Regional amyloid burden was associated with longer light and deep sleep in amyloid-positive individuals. Higher education was linked to better sleep efficiency. DISCUSSION: Sleep changes may serve as early indicators of cognitive dysfunction and regional amyloid accumulation.

Indexed as

AmyloidBrainCognitive DysfunctionSleepSleep Wake DisordersAgedFemaleHumansMalePositron-Emission TomographyAmyloid11C‐PiB (amyloid) PETcognitive impairmentEEG sleep monitoring

Identifiers

PMID41949989
PMCPMC13060651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.