Evidence map›Paper›PMID 41949705›Full record

ArticleClinical and experimental nephrology2026

Relationship between iron deficiency and corrected QT-interval prolongation in Japanese patients undergoing maintenance hemodialysis.

Sho Sasaki, Kiichiro Fujisaki, Hikaru Uematsu, Masato Nishimura, Toshiaki Nakano, Masanori Abe, Norio Hanafusa, Nobuhiko Joki

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Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Sho Sasaki *Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.ORCID http://orcid.org/0000-0002-6744-5931
Kiichiro Fujisaki *Department of Nephrology, Iizuka Hospital, Fukuoka, Japan.ORCID http://orcid.org/0000-0003-0395-9770
Hikaru UematsuDivision of Nephrology, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Tokyo, Meguro-Ku, 153-8515, Japan.ORCID http://orcid.org/0000-0002-4485-8522
Masato NishimuraTojinkai Hospital, Kyoto, Japan.ORCID http://orcid.org/0000-0003-4540-6402
Toshiaki NakanoDepartment of Medical and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-9235-5615
Masanori AbeDivision of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5641-4996
Norio HanafusaDepartment of Blood Purification, Tokyo Women's Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0563-3320
Nobuhiko JokiDepartment of General Medicine, Iwase Satellite for Teaching And Research (STAR), Fukushima Medical University, Fukushima, Fukushima Prefecture, Japan. jokinobuhiko@gmail.com.ORCID http://orcid.org/0000-0003-0285-8388

Funding

KAKENHI 23K16353
6 · The paper itself

Abstract

backgroundThe cause of QT-interval prolongation in patients undergoing hemodialysis (HD) remains unknown. Lower transferrin saturation (TSAT) is associated with cardiovascular complications in patients with chronic kidney disease. This study aimed to evaluate the association of iron deficiency with QT-interval prolongation in patients undergoing HD.

methodsThis cross-sectional study included adult patients undergoing maintenance HD who were enrolled in the 2020 Japanese Society for Dialysis Therapy Renal Data Registry. Multivariable logistic regression analysis was performed with serum ferritin level and TSAT as explanatory variables and QT-interval prolongation (corrected QT interval > 500 ms) as the outcome. A restricted cubic spline (RCS) with three knots was used to explore potential non-linear relationships.

resultsOf 175,448 patients, 13,343 (7.6%) experienced QT-interval prolongation. In the multivariable analysis, the RCS between logged serum ferritin level and QT-interval prolongation was non-linear, indicating that QT-interval prolongation does not increase at a constant rate with higher ferritin levels. Contrastingly, the RCS between TSAT and QT-interval prolongation showed an inverse relationship, indicating that lower TSAT is associated with a higher risk of QT-interval prolongation.

conclusionsLow TSAT is associated with QT-interval prolongation in patients undergoing HD. Circulatory iron deficiency may play a role in prolonging ventricular repolarization time, independent of other risks in patients undergoing HD. These findings could help prevent and manage QT-interval prolongation.

Indexed as

Anemia, Iron-DeficiencyIron DeficienciesLong QT SyndromeRenal DialysisRenal Insufficiency, ChronicAgedCross-Sectional StudiesEast Asian PeopleElectrocardiographyFemaleFerritinsHumansJapanMaleMiddle AgedRisk FactorsFerritinsTransferrinHemodialysisIron deficiencyQT interval

Identifiers

PMID41949705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.