Evidence map›Paper›PMID 41949669›Full record

ReviewHistochemistry and cell biology2026

Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives.

Qiaoli Dai, Zuping Wu, Ying Wang, Na Wu, Chenyu Wang, Jiejun Shi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiaoli Dai *Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310016, China.
Zuping Wu *Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310016, China.
Ying WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310016, China.
Na WuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310016, China.
Chenyu WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310016, China.
Jiejun ShiStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310016, China. sjiejun@zju.edu.cn.

Funding

he Key Research Project of National Traditional Chinese Medicine Comprehensive Reform Demonstration Zone Science and Technology Co-construction Project 2025 GZY-KJS-ZJ-2025-094the National Natural Science Foundation of China 82170984the National Natural Science Foundation of China 82501200the Open project of Guangxi Key Laboratory of the Rehabilitation and Reconstruction for oral and Maxillofacial Research GXKLOMRR2402the Zhejiang Provincial Natural Science Foundation of China LQ24H140004
6 · The paper itself

Abstract

Joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), anterior cruciate ligament (ACL) injury, and shoulder instability, severely compromise human health. Periostin (POSTN), a multifunctional extracellular matrix protein enriched in connective tissues, exerts multifaceted roles in joint biology. It supports normal tissue development, but under pathological conditions, it binds to cell-surface receptors. This interaction activates downstream signaling cascades, such as Wnt/β-catenin, nuclear factor κB (NF-κB), and transforming growth factor β (TGF-β), thereby propelling disease progression. Notably, POSTN's functional specificity is dictated by its splice variant profiles and cellular localization, with the tissue-specific expression and functional divergence of these variants emerging as a pivotal research focus. Recent evidence links POSTN expression levels to the severity of joint-related diseases, highlighting its potential as a diagnostic biomarker. This review summarizes the core roles and underlying mechanisms of POSTN in joint physiology and pathology, laying a theoretical foundation for clinical translation.

Indexed as

Joint DiseasesJointsPeriostinAnimalsCell Adhesion MoleculesHumansOsteoarthritisCell Adhesion MoleculesPeriostinPOSTN protein, humanAlternative SplicingAnterior cruciate ligamentIntervertebral disc degenerationOsteoarthritisPeriostinRheumatoid arthritis

Identifiers

PMID41949669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.