Evidence map›Paper›PMID 41949613›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2026

Diallyl disulfide reduces oxidative stress to mitigate uranium tailings radiation-induced damage to the hematopoietic system.

Yuanyun Wei, Linwei Li, Yuanyuan Li, Qingyu Wang, Yaqi Gong, Shuang Wei, Fang Yi, Caimao Guo, Wenyu Wu, Yueqiu Yu and 4 more

Abstract read
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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuanyun WeiInstitute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Linwei LiThe Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Yuanyuan LiInstitute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Qingyu WangInstitute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Yaqi GongInstitute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Shuang WeiInstitute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Fang YiThe Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Caimao GuoInstitute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Wenyu WuInstitute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Yueqiu YuInstitute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Xiang LinThe Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Ye KuangThe Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Hui QinInstitute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. lanniaoqinhui@163.com.
Lan YiInstitute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. yilanoky@126.com.

Funding

Hunan Natural Science Foundation 2022JJ30478, 2025JJ50638Innovative Entrepreneurship Training Program for college students in Hunan Province 2023-4827Key Scientific Research Project of Hunan Health Commission No.202102051816Scientific Research Innovation Project for Graduate Students in Hunan Province CX20230991
6 · The paper itself

Abstract

The blood system is sensitive to radiation, making it vulnerable to damage. Diallyl disulfide (DADS), a primary bioactive compound derived from allicin degradation, has shown significant potential in tumor prevention and treatment. This study investigates the role and mechanisms of DADS in mitigating radiation-induced damage to the blood system, thereby providing both experimental evidence and theoretical insights for further research on radiation damage protection. A C57BL/6J mouse model was exposed to low-dose ionizing radiation and treated with DADS; spleen red pulp area, bone marrow morphology, peripheral blood indices, and erythropoietin levels were addressed. In addition, a GM12878 human B lymphocyte cell model was used to evaluate the effects of DADS on cell viability and apoptosis during irradiation. Our results show that DADS reduces radiation-induced damage both in mouse and GM12878 cell models. Specifically, DADS shields GM12878 cell apoptosis from radiation by reducing reactive oxygen species (ROS) production, thereby exerting a protective effect on the radiation damage to the blood system. Our findings underscore the potential of DADS as a protective agent against radiation-induced damage to the blood system.

Indexed as

ApoptosisBlood systemDiallyl disulfideIonizing radiationRadiation damageROS

Identifiers

PMID41949613

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.