ArticleJournal of medical virology2026
Concordance and Acceptability of Self- Vs. Clinician-Collected Anorectal Swabs for HPV Genotyping in Gay, Bisexual and Other Men Who Have Sex With Men in Metropolitan Barcelona.
Article in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Squamous cell carcinoma of the anus (SCCA), caused by high-risk human papillomavirus (HR-HPV) genotypes, is a growing concern among gay, bisexual, and other men who have sex with men and transgender individuals, particularly those living with HIV. Early detection of precursor lesions is crucial, yet current screening methods face barriers in access and acceptability. Anal self-sampling has emerged as a promising patient-centered alternative. This study evaluates the diagnostic accuracy and feasibility of self-collected anal swabs for HPV genotyping compared to clinician-collected swabs among the target population. A cross-sectional, multicenter study was conducted in the metropolitan area of Barcelona, enrolling 151 participants. Participants provided self- and clinician-collected anal samples, obtained sequentially. Extended genotyping was performed to detect 28 individual HPV genotypes. Diagnostic performance was evaluated using clinician-collected samples as the reference standard, and concordance was assessed using McNemar's test and Cohen's κ statistic. Feasibility was measured via a questionnaire. Participants had a median age of 43 years, and 53.0% were living with HIV. Overall, HPV was detected in 89.9% of self- and 92.6% of clinician-collected samples. Agreement was high 96.0%, with a κ value of 0.75 (95% CI: 0.55-0.94). No significant differences were found between methods (p = 0.22). Sensitivity was 96.4% (95% CI: 91.8-98.4), and specificity 90.9% (95% CI: 62.3-98.4), with similar accuracy for HR-HPV and HPV16 types. Most participants rated self-sampling acceptable and feasible. Anal self-sampling shows high accuracy and strong feasibility, supporting its use as a viable and user-friendly strategy to enhance HPV screening in key populations at risk for SCCA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.