ArticleThe breast journal2026
Treatment Regimens and Response Rates in Early TNBC: A Review of Real-World Practice in the Second Decade of the 21st Century.
Article in The breast journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Treatment Regimens and Response Rates in Early TNBC: A Review of Real-World Practice in the Second Decade of the 21st Century.The breast journal · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
BACKGROUND AND
aimsReal-world evidence on the treatment of early triple-negative breast cancer (TNBC) remains limited. This study provides an overview of neoadjuvant chemotherapy (NACT) regimens used in the 2010s of the 21
methodsIn this retrospective, noninterventional, single-center study, we analyzed data from TNBC patients diagnosed between January 1, 2010, and December 31, 2018, registered in the Tumor Centre Regensburg. Data included demographics, pathology, treatment regimen, recurrence, and survival, with follow-up extending to December 2023. Outcomes included pathologic complete response (pCR), overall survival (OS), and recurrence-free survival (RFS).
resultsA total of 319 patients were included. Among them, 132 patients (41.4%) received NACT with epirubicin/cyclophosphamide (EC) and paclitaxel (EC-T), 74 patients (23.2%) received NACT with EC-T and platinum (EC-P/T), and 22 patients (6.9%) received NACT with EC-P/nab-paclitaxel (EC-P/nabP). Other NACT protocols were administered in 91 (28.5%) patients. A pCR occurred in 49.8% of NACT patients, with a 37.1% rate in the subgroup without platinum. Addition of platinum significantly increased the pCR rate to 54.1% compared to EC-T (odds ratio [OR] 3.476, 95% confidence interval [CI] 1.655-7.300, p = 0.001). EC-P/nabP led to a significant increase in pCR rate to 77.3% (OR 8.767, 95% CI 2.421-31.744, p < 0.001).
conclusionThe evidence from clinical trials was quickly incorporated into clinical practice, leading to higher pCR rates and benefits for patients. In the next step, the implementation of immune checkpoint inhibitors in real-world practice will be analyzed.
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