Evidence map›Paper›PMID 41949299›Full record

ArticleJournal of bacteriology2026

RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes in

Autumn N Pope, Varun R Bavda, Megan L Schumacher, Alicia G Mendoza, Anne M Stringer, Caleb P Mallery, Anna Czachor, Amanda F Kurtz, Biqing Liang, Xia Ke and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Autumn N PopeDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0009-0005-4409-009X
Varun R BavdaDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Megan L SchumacherDepartment of Biomedical Sciences, College of Integrated Health Sciences, University at Albany, Albany, New York, USA.
Alicia G MendozaDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Anne M StringerDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Caleb P MalleryDepartment of Biomedical Sciences, College of Integrated Health Sciences, University at Albany, Albany, New York, USA.ORCID 0009-0008-1114-513X
Anna CzachorDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Amanda F KurtzDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Biqing LiangDepartment of Biomedical Sciences, College of Integrated Health Sciences, University at Albany, Albany, New York, USA.
Xia KeCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Joseph T WadeDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-9779-3160
Jon E PaczkowskiDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-8286-3808

Funding

Unexpected complexity in bacterial genomesR35GM144328 · NIGMS · WADSWORTH CENTER · PI Joseph Thomas Wade · 2022 to 2026
$2.6M
RNA Science and Technology in Health and DiseaseT32GM132066 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Thomas J Begley · 2019 to 2026
$1.8M
American Lung Association INALA2023Cystic Fibrosis Foundation PACZKO21G0New York Community Trust P19-000454NIGMS NIH HHS R01GM14436101NIGMS NIH HHS R35GM144328NIGMS NIH HHS T32GM132066
6 · The paper itself

Abstract

Quorum sensing enables bacteria to coordinate gene expression in response to population density through the detection of small-molecule signals. In gram-negative bacteria, LuxR-type transcription factors bind acyl-homoserine lactones to regulate collective behaviors, yet how ligand sensitivity is tuned to shape transcriptional outcomes remains poorly defined. In

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialPhenazinesPseudomonas aeruginosaQuorum Sensing4-ButyrolactoneLigandsPromoter Regions, Genetic4-ButyrolactoneBacterial ProteinsLigandsN-butyrylhomoserine lactonephenazinePhenazinesRhlR protein, Pseudomonas aeruginosaacyl-homoserine lactonegene regulationphenazine regulationquorum sensingsignal transduction

Identifiers

PMID41949299
PMCPMC13192270

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.