Evidence map›Paper›PMID 41949289›Full record

ArticleeLife2026

Permissive and instructive

Yajun Wang, Maik Hintze, Jinbao Wang, Hengxun Tao, Patrick Petzsch, Karl Köhrer, Longfei Cheng, Peng Zhou, Jianlin Wang, Zhaofu Liao and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yajun WangInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.ORCID https://orcid.org/0009-0004-6955-0454
Maik HintzeInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Jinbao WangInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Hengxun TaoInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Patrick PetzschBiological and Medical Research Centre (BMFZ), Medical Faculty, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany.
Karl KöhrerBiological and Medical Research Centre (BMFZ), Medical Faculty, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany.
Longfei ChengInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Peng ZhouInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Jianlin WangCollege of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.
Zhaofu LiaoKey Laboratory of Regenerative Medicine, Ministry of Education, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, China.
Xu-Feng QiKey Laboratory of Regenerative Medicine, Ministry of Education, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0002-5911-071X
Dongqing CaiKey Laboratory of Regenerative Medicine, Ministry of Education, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, China.
Thomas BartolomaeusInstitute of Evolutionary Biology and Animal Ecology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Karl SchillingInstitute of Anatomy, Department of Cell Biology, University of Bonn, Medical Faculty, Bonn, Germany.
Joerg WiltingDeparment of Anatomy and Cell Biology, University Medical School Goettingen, Goettingen, Germany.
Stefanie KuertenInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Georgy KoentgesLaboratory of Systems Biomedicine and Evolution, School of Life Sciences, University of Warwick, Coventry, United Kingdom.
Ketan PatelSchool of Biological Sciences, University of Reading, Reading, United Kingdom.ORCID https://orcid.org/0000-0002-7131-749X
Qin PuInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.
Ruijin HuangInstitute of Neuroanatomy, University of Bonn, Medical Faculty, Bonn, Germany.ORCID https://orcid.org/0000-0003-0467-2907

Funding

Deutsche Forschungsgemeinschaft DFG-Hu 729/13
6 · The paper itself

Abstract

The positioning of limbs along the anterior-posterior axis varies widely across vertebrates. The mechanisms controlling this feature remain to be fully understood. For over 30 years, it has been speculated that

Indexed as

Body PatterningExtremitiesForelimbGene Expression Regulation, DevelopmentalGenes, HomeoboxHomeodomain ProteinsAnimalsChick EmbryoLimb BudsMesodermHomeodomain Proteinschickendevelopmental biologyforelimb inductionforelimb positioninghomeobox genesinstructivepermissive

Identifiers

PMID41949289
PMCPMC13061413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.