Evidence map›Paper›PMID 41949152›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2026

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis.

Babak Moradi, Miriam T Jackson, Cindy C Shu, Susan M Smith, Margaret M Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R Scanzello and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Babak MoradiRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.ORCID https://orcid.org/0000-0003-1714-2171
Miriam T JacksonRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Cindy C ShuRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Susan M SmithRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Margaret M SmithRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Sanaa ZakiRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Hadrian PlatzerRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Nils RosshirtOrthopedic Research Center, Kiel University, Kiel, Germany.
David GiangrecoDivision of Rheumatology, Rush University Medical Center, Chicago, Illinois.
Carla R ScanzelloDivision of Rheumatology, Rush University Medical Center, Chicago, Illinois.
Christopher B LittleRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Funding

Arthritis AustraliaAustralian National Health and Medical Research Council (NHMRC: Project Grant APP1045890) APP1045890Deutsche Forschungsgemeinschaft 199129044Deutsche Forschungsgemeinschaft 277277765Hillcrest Foundation through Perpetual Philanthropies
6 · The paper itself

Abstract

objectiveIdentification of osteoarthritis (OA)-specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA-associated cellular events.

methodsWe undertook detailed temporal flow cytometric and messenger RNA (mRNA) expression analysis in mice after sham or destabilization of the medial meniscus (DMM) surgery. This was compared with patients with meniscal injury and OA, evaluating the role of synovial monocytes/macrophages versus lymphocytes in catabolic metalloproteinase secretion in vitro. We determined the effect of transient or delayed systemic T cell depletion on DMM-induced OA pathology.

resultsOA-inducing/DMM and non-OA-inducing/sham surgery had an identical synovial monocyte/macrophage number, activation, and polarization. The number and activation of synovial (not splenic or peripheral blood) CD4

conclusionWe identify a hitherto unappreciated pathophysiologic role of acute T cell activation after joint injury in long-term posttraumatic OA risk, providing a novel diagnostic and therapeutic target.

Indexed as

Knee InjuriesOsteoarthritis, KneeSynovial MembraneTibial Meniscus InjuriesT-LymphocytesAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalDisease ProgressionFemaleFlow CytometryHumansLymphocyte ActivationMacrophagesMale

Identifiers

PMID41949152
PMCPMC13507569

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.