Evidence map›Paper›PMID 41949015›Full record

ArticlePediatric dermatology

A Case of Pediatric Spitz Melanoma With a ZEB2::ALK Fusion.

Nathanael C Jensen, Shadai Gociman, Sarah D Cipriano, Casey Mehrhoff

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathanael C JensenDepartment of Dermatology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-3952-4699
Shadai GocimanDepartment of Dermatology, University of Utah, Salt Lake City, Utah, USA.
Sarah D CiprianoDepartment of Dermatology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-0888-1458
Casey MehrhoffDeparment of Pediatric Oncology, University of Utah, Salt Lake City, Utah, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a rare case of Spitz melanoma in a 3-year-old male patient with a ZEB2::ALK fusion. This ALK-fused tumor exhibited aggressive behavior, recurring after an initial wide local excision and progressing despite neoadjuvant immunotherapy with a PD-1 inhibitor. Following a second surgical resection and adjuvant radiation therapy, the patient was started on adjuvant targeted therapy with lorlatinib, an ALK kinase inhibitor. This report illustrates the role of immunotherapy and targeted therapy in melanoma treatment.

Indexed as

Anaplastic Lymphoma KinaseMelanomaNevus, Epithelioid and Spindle CellSkin NeoplasmsZinc Finger E-box Binding Homeobox 2Child, PreschoolHumansMaleALK protein, humanAnaplastic Lymphoma KinaseZEB2 protein, humanZinc Finger E-box Binding Homeobox 2cutaneous oncologygeneticsmelanomapediatric dermatologySpitz tumor

Identifiers

PMID41949015
PMCPMC13423131

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.