Observational studyActa obstetricia et gynecologica Scandinavica2026
Normative range for MRI amniotic fluid volume from 16 to 36 gestational weeks: Absolute and relative values, and correlation to ultrasound.
Observational study in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04142606 (LUMIERE on the FETUS), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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LUMIERE on the FETUS : A Study on the Added Value of Fetal MRI
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAmniotic fluid volume (AFV) is clinically important, yet ultrasound-based indices correlate poorly with true volume. MRI provides accurate volumetry, but normative reference data for AFV remain scarce. This study aimed to establish MRI-based gestational-age reference ranges for AFV and the AFV-to-fetal body volume ratio (AFV/FBV) from 16 to 36 weeks' gestation and to compare ultrasound amniotic fluid index (AFI) with MRI-derived AFV. MATERIAL AND
methodsProspective observational cohort study conducted at a single tertiary fetal imaging center (LUMIERE, Necker Hospital, Paris, France). Healthy singleton pregnancies between 16 and 36 gestational weeks were included; pregnancies with fetal anomalies or maternal complications were excluded. T2-weighted MRI with manual segmentation was performed to quantify AFV and fetal body volume. In a predefined subset, AFI was measured on same-day ultrasound. The main outcomes were AFV, AFV/FBV ratio, and their gestational-age normative ranges. The secondary outcome was the correlation between AFI and MRI-derived AFV. Percentile curves were derived using quadratic polynomial modeling.
trial registrationClinicalTrials.gov NCT04142606.
results322 pregnancies were included (median gestational age 27.9 weeks; 45% male). AFV increased with gestational age (β = 6.61), peaking around 31 weeks, whereas AFV/FBV ratio declined (β = -0.08). No sex differences were observed. Weekly distributions were normally distributed. Quadratic polynomial modeling yielded physiologically plausible percentile curves (R
conclusionsThis study provides the first MRI-based normative charts for AFV and AFV/FBV ratio between 16 and 36 weeks' gestation. The AFV/FBV ratio represents a novel physiological marker integrating fetal growth and fluid balance. These reference ranges may support future research and clinical decision-making.
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