Evidence map›Paper›PMID 41948911›Full record

ArticleMediators of inflammation2026

EZH2-Mediated Epigenetic Modifications Induce Pyroptosis in Dental Pulp Endothelial Cells via Activation of NLRP6 Inflammasome During Pulpitis Development.

Weilin Zhou, Weili Huang, Hongjing You, Zhixi Huang, Jingye Zhou, Yi Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weilin ZhouHospital of Stomatology, The First Affiliated Hospital, Clinical Research Platform for Interdiscipline, School of Stomatology, Jinan University, Guangzhou, China, jnu.edu.cn.ORCID https://orcid.org/0009-0009-2615-6306
Weili HuangHospital of Stomatology, The First Affiliated Hospital, Clinical Research Platform for Interdiscipline, School of Stomatology, Jinan University, Guangzhou, China, jnu.edu.cn.ORCID https://orcid.org/0009-0009-7200-6472
Hongjing YouSchool of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China, gzucm.edu.cn.ORCID https://orcid.org/0009-0008-1725-4644
Zhixi HuangHospital of Stomatology, The First Affiliated Hospital, Clinical Research Platform for Interdiscipline, School of Stomatology, Jinan University, Guangzhou, China, jnu.edu.cn.ORCID https://orcid.org/0009-0005-1653-7771
Jingye ZhouHospital of Stomatology, The First Affiliated Hospital, Clinical Research Platform for Interdiscipline, School of Stomatology, Jinan University, Guangzhou, China, jnu.edu.cn.ORCID https://orcid.org/0009-0008-4860-8820
Yi HuangHospital of Stomatology, The First Affiliated Hospital, Clinical Research Platform for Interdiscipline, School of Stomatology, Jinan University, Guangzhou, China, jnu.edu.cn.ORCID https://orcid.org/0000-0002-9803-9274

Funding

Guangzhou Science and Technology Planning Project 2023A03J0590
6 · The paper itself

Abstract

objectivesRecent studies suggest that alleviating pyroptosis may be an effective strategy for treating inflammation. This research explores the changes in cellular composition and pyroptotic pathways in dental pulp tissue during pulpitis and preliminarily validates the regulatory role of EZH2 in lipopolysaccharide (LPS)-induced pyroptosis of vascular endothelial cells (ECs) via NLRP6, aiming to provide a theoretical foundation for understanding pulpitis mechanisms.

methodsBioinformatics analysis of public single-cell RNA sequencing (scRNA-seq) and microarray data, together with RNA-seq of EZH2

resultsBioinformatics analysis revealed a strong association between pulpitis and EC pyroptosis. RNA-seq further demonstrated that EZH2 deficiency was associated with enhanced pyroptotic responses in ECs. In vitro, EZH2 inhibition or NLRP6 knockdown markedly attenuated LPS-induced inflammasome activation and pyroptosis in EOMA cells. This illustrates that the EZH2/NLRP6 axis plays a critical regulatory role in EC pyroptosis and suggests its potential as a therapeutic target in pulpitis.

conclusionsIn summary, this study establishes ECs as key regulators in pulpitis inflammation, highlighting EZH2's role in modulating NLRP6 and the potential mechanism of pyroptosis in ECs.

Indexed as

Dental PulpEndothelial CellsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticInflammasomesPulpitisPyroptosisAnimalsHumansLipopolysaccharidesMiceMice, Inbred C57BLEnhancer of Zeste Homolog 2 ProteinInflammasomesLipopolysaccharidesEZH2inflammasomeNLRP6pulpitispyroptosisvascular endothelial cell

Identifiers

PMID41948911
PMCPMC13058821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.