Observational study in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005131 (Atherosclerosis Risk in Communities), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1985 to 2007ConditionsAtherosclerosis, Coronary Disease, Coronary Heart Disease Risk Reduction, Diabetes Mellitus
3 · Its place in the literature
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Souvik SenDepartment of Neurology, University of South Carolina, School of Medicine, Columbia (S.S., S.M.W., A.E.B.).ORCID 0000-0002-0886-2364
Julie T MarchesanDivision of Comprehensive Oral Health/Periodontology (J.T.M.), University of North Carolina, Chapel Hill.ORCID 0000-0003-0610-3193
Kevin MossDepartment of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis (K.M.).ORCID 0000-0003-2332-1774
Stefanie M WoodDepartment of Neurology, University of South Carolina, School of Medicine, Columbia (S.S., S.M.W., A.E.B.).ORCID 0009-0008-9642-8891
Alana E BartonDepartment of Neurology, University of South Carolina, School of Medicine, Columbia (S.S., S.M.W., A.E.B.).
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.).ORCID 0000-0002-2225-8323
Elsayed Z SolimanDepartment of Epidemiology and Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (E.Z.S.).ORCID 0000-0001-5632-8150
Jared W MagnaniDepartment of Medicine, University of Pittsburgh Medical Center, PA (J.W.M.).ORCID 0000-0002-5075-3604
Michelle C JohansenDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (M.C.J.).ORCID 0000-0003-0393-3589
Kamakshi LakshminarayanDepartment of Epidemiology & Community Health and Department of Neurology, University of Minnesota, Minneapolis (K.L.).ORCID 0000-0002-8564-8986
Wayne D RosamondDepartment of Epidemiology, Gillings School of Public Health (W.D.R.), University of North Carolina, Chapel Hill.ORCID 0000-0001-5271-074X
James BeckDepartment of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry (J.B.), University of North Carolina, Chapel Hill.ORCID 0000-0001-5415-8311
Funding
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS)R01MD009738 · NIMHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SEN, SOUVIK · 2015 to 2019
$3.4M
Training Program for the Next Generation of Oral Health Researchers (NextGen)T90DE021986 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVERETT, ERIC T. · 2011 to 2017
$2.3M
GENOME-WIDE ASSOCIATION STUDY OF PERIODONTAL DISEASER01DE021418 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OFFENBACHER, STEVEN · 2011 to 2012
backgroundPrior studies have demonstrated an association between oral infection and both incident stroke and atrial fibrillation (AF), a major cause of cardioembolic stroke. However, the impact of preventive oral behaviors such as dental flossing on incident stroke and AF remains unclear. We evaluated the relationship between flossing, incident stroke subtypes, and AF from the ARIC study (Atherosclerosis Risk in Communities).
methodsWe conducted a prospective cohort study using data from the ARIC study. Flossing was assessed via a structured questionnaire at visit 4 (1996-1998). Participants were censored at the first stroke, death, or loss-to-follow-up through December 31, 2021. Incident ischemic stroke and subtypes were evaluated using Cox proportional hazards models, adjusting for cardiovascular risk factors, education, regular brushing, dental care utilization, periodontal disease, and dental caries.
resultsAmong 6200 dentate participants without prior stroke, 65% (n=4049) reported regular flossing. Flossers had significantly lower prevalence of vascular risk factors, periodontal disease, and dental caries at baseline. Flossers had lower IL (interleukin)-6 levels in crude analysis, but this difference was explained by confounding from age, body mass index, and smoking. CRP (C-reactive protein) levels did not differ between groups. During a median 23.7 years follow-up, 434 ischemic strokes occurred, including 146 thrombotic, 102 cardioembolic, 95 lacunar, and 91 other ischemic subtypes. Nonflossers had higher rates of both ischemic stroke (8.7% versus 6.1%) and nonstroke mortality (40.8% versus 34.5%). Flossing was associated with lower risk of ischemic stroke (adjusted hazard ratio, 0.77 [95% CI, 0.64-0.96]), cardioembolic stroke (adjusted hazard ratio, 0.60 [95% CI, 0.38-0.94]), and AF (adjusted hazard ratio, 0.88 [95% CI, 0.77-0.99]) with dose-response relationship (
conclusionsRegular flossing was associated with a lower risk of ischemic stroke, primarily driven by reductions in cardioembolic stroke and AF, independent of other oral health behaviors. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00005131.
Indexed as
Atrial FibrillationDental Devices, Home CareEmbolic StrokeIschemic StrokeAgedFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk Factorsatrial fibrillationbody mass indexcardiovascular diseaseischemic strokeoral health
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dental Flossing May Lower the Risk for Incident Ischemic Stroke, Cardioembolic Stroke Subtype, and Atrial Fibrillation. · full record | OpenQuestion