Dual-mechanism of phytochemicals in cancer therapy: synergistic anti-angiogenic potency in cancer and proangiogenic impact against chemotherapy-induced cytotoxicity in vital organs.

Deiaa E Elsayed Abouzed, Nervana M K Bayoumy, Hanan Hagar, Safwat M Rabea, Hamada Hashem, Hazim O Khalifa

Abstract readReview

In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deiaa E Elsayed AbouzedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

Nervana M K BayoumyDepartment of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Hanan HagarDepartment of Biology, University of Arkansas at Little Rock, Little Rock, AR, United States.

Safwat M RabeaMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Hamada HashemPharmaceutical Chemistry Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

Hazim O KhalifaDepartment of Veterinary Medicine, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis is essential for tumor growth and metastasis, yet physiological angiogenesis is equally critical for tissue repair and endothelial homeostasis. This creates a therapeutic dilemma: suppressing tumor neovascularization without impairing vascular integrity in healthy organs, particularly under cytotoxic chemotherapy. This review summarizes key pro- and anti-angiogenic pathways that regulate tumor vascularization, highlights limitations of current anti-angiogenic therapies (including resistance and delivery barriers), and synthesizes evidence that selected phytochemicals exert

Indexed as

angiogenesisantiangiogenetic therapychemotherapy toxicitycytoprotectionphytochemicals

Identifiers

PMID41948735

DOI10.3389/fphar.2026.1783390

PMCPMC13050877

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.