ArticleFrontiers in pediatrics2026
Early targeted neonatal echocardiography identifies biventricular dysfunction and pulmonary hypertension associated with death or severe bronchopulmonary dysplasia in infants born before 29 weeks' gestation.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extremely preterm infants are at increased risk of haemodynamic instability during early postnatal transition. The contribution of early biventricular dysfunction and pulmonary hypertension to mortality and severe respiratory morbidity remains incompletely defined. Objectives: To determine whether early targeted neonatal echocardiography (TNE) markers of biventricular function and pulmonary hypertension are associated with death or severe bronchopulmonary dysplasia (BPD) in infants born before 29 weeks' gestation. Methods: We conducted a retrospective cohort study of inborn infants <29 weeks' gestation admitted to a tertiary neonatal intensive care unit between October 2023 and June 2025. All infants underwent standardized TNE within 72 h of birth. Echocardiographic indices of left and right ventricular systolic function, ductal shunt direction, and pulmonary hypertension were compared between survivors and non-survivors, and among survivors with and without severe BPD (Jensen grade 3). The primary outcome was death before 36 weeks' postmenstrual age or severe BPD. Results: Of 122 infants included, 24 (19.7%) died and 33 of 98 survivors (33.7%) developed severe BPD. Survivors demonstrated significantly better biventricular systolic performance and more favourable pulmonary haemodynamics, including higher ventricular outputs, greater tricuspid annular plane systolic excursion, higher pulmonary artery acceleration time-to-right ventricular ejection time ratios, and lower eccentricity indices (all Conclusions: In extremely preterm infants, early TNE markers of biventricular dysfunction and pulmonary hypertension were associated with death and severe respiratory morbidity. These findings suggest that early haemodynamic phenotype may have prognostic relevance and warrant further prospective investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.