ArticleWorld journal of otorhinolaryngology - head and neck surgery2026
Early Initiation of Adjuvant Therapy Following Pediatric Endoscopic Endonasal Surgery for Tumors.
Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate complication rates of early adjuvant therapy initiation in pediatric patients with endoscopic endonasal resection for skull base tumors. Design: Retrospective case series of pediatric patients (0-18 years old) with skull base tumors who underwent endoscopic endonasal resection between 2013 and 2023. The median follow-up was 4.21 years. Setting: Single, urban academic pediatric center. Participants: Patients who received radiation within 3 months and/or chemotherapy within 2 weeks of endoscopic endonasal resection. Main Outcome Measures: Primary outcomes were perioperative and adjuvant therapy-related complications including reconstruction failure. Secondary outcomes were recurrence and overall survival. Results: This study included 16 patients (radiation [ Conclusions: A majority of our patient cohort experienced intraoperative CSF leaks resulting in a high rate of complex endonasal reconstructions. Adjuvant treatment postoperatively did not incur significant complications, despite initiation of radiation as early as postoperative day 1 or chemotherapy as early as postoperative day 0, demonstrating preliminary support of the safety of early adjuvant therapy initiation following endoscopic endonasal procedures in the pediatric skull base tumor population.
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