ArticleOsteoarthritis and cartilage open2026
Understanding the use of spheroids and pellets in the chondrogenic differentiation of human stem cells.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Objectives: The limited regenerative capacity of cartilage tissue and the high morbidity associated with injuries and diseases have driven the search for innovative regenerative medicine strategies. The objective of the study was to compare the chondrogenic differentiation of human MSCs in conventional pellet cultures to that of spheroids generated using an innovative microwell system. Design: Human bone marrow mesenchymal stem cells (hBMSCs) were isolated and cultured in either pellet or microwell systems. Upon induction of chondrogenesis, gene expression and extracellular matrix deposition were analysed. Results: We found that chondrogenic pellets outperformed spheroids based on the expression levels of chondrogenic markers, such as Conclusions: This study demonstrates the complexities of MSC's chondrogenesis across different aggregate dimensions in balancing chondrogenesis and hypertrophy. Overall, these findings indicate that the culture system choice should reflect specific biological and translational aims, with each system offering complementary strengths.
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