Evidence map›Paper›PMID 41948591›Full record

ArticleFrontiers in medicine2026

Evaluation of aggressive posterior retinopathy of prematurity (AP-ROP) in the German Retina.net ROP registry.

Marie-Christine Bründer, Johanna M Pfeil, Marlene Sassmannshausen, Navid Farassat, Birgit Lorenz, Lyubomyr Lytvynchuk, Helge Breuss, Teresa Barth, Christos Skevas, Karsten Hufendiek and 13 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Marie-Christine Bründer *Department of Ophthalmology, University Medicine Greifswald, Greifswald, Germany.
Johanna M Pfeil *Department of Ophthalmology, University Medicine Greifswald, Greifswald, Germany.
Marlene SassmannshausenDepartment of Ophthalmology, University Medicine Bonn, Bonn, Germany.
Navid FarassatEye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Birgit LorenzDepartment of Ophthalmology, Eye Clinic, Justus-Liebig-University Giessen, University Hospital Giessen and Marburg GmbH, Campus Giessen, Giessen, Germany.
Lyubomyr LytvynchukDepartment of Ophthalmology, Eye Clinic, Justus-Liebig-University Giessen, University Hospital Giessen and Marburg GmbH, Campus Giessen, Giessen, Germany.
Helge BreussDepartment of Ophthalmology, HELIOS Klinikum Berlin-Buch, Berlin, Germany.
Teresa BarthDepartment of Ophthalmology, University of Regensburg, Regensburg, Germany.
Christos SkevasDepartment of Ophthalmology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Karsten HufendiekUniversity Eye Hospital, Hannover Medical School, Hannover, Germany.
Tim U KrohneDepartment of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Daniela SuesskindUniversity Eye Hospital, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
Anna Nguyen-HöhlDepartment of Ophthalmology, University Medical Center Goettingen, Goettingen, Germany.
Marian LieglDepartment of Ophthalmology, Vivantes Klinikum Neukoelln, Berlin, Germany.
Barbara GlitzDepartment of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
Ameli Gabel-PfistererDepartment of Ophthalmology, Klinikum Ernst von Bergmann, Potsdam, Germany.
Stefanie GniesmerDepartment of Ophthalmology, University of Luebeck, Luebeck, Germany.
Vinodh KakkasseryDepartment of Ophthalmology, Klinikum Chemnitz gGmbH, Chemnitz, Germany.
Sabine BaumgartenDepartment of Ophthalmology, University Hospital RWTH, Aachen, Germany.
Rainer GuthoffDepartment of Ophthalmology, Faculty of Medicine, University of Duesseldorf, Duesseldorf, Germany.
Lars ChoritzDepartment of Ophthalmology, Otto von Guericke University, Magdeburg, Germany.
Andreas StahlDepartment of Ophthalmology, University Medicine Greifswald, Greifswald, Germany.
German Retina.net ROP Registry Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Aggressive (posterior) retinopathy of prematurity (A-ROP/AP-ROP) may progress rapidly into tractional retinal detachment if not treated timely. Fortunately, this type of treatment-warranted ROP is rare in developed countries. As a consequence, data on risk factors for development of this aggressive form of ROP is sparse. In this study, we aim to analyse the risk factors for the development of AP-ROP using data from the German Retina.net ROP registry and report functional outcomes of patients treated for AP-ROP. Methods: We assessed the observational German Retina.net ROP registry for infants born between 2011 and 2020 and treated for unilateral or bilateral aggressive posterior ROP (AP-ROP) ( Results: Of 350 infants treated for any ROP, 21 (6%) were diagnosed with unilateral or bilateral AP-ROP [38 of 686 eyes (5.5%)], predominantly in zone I (77%). Infants with AP-ROP were born at a significantly younger gestational age (24.3 vs. 25.4 weeks; Conclusion: Our study confirmed known risk factors for the development of AP-ROP such as low GA and low birth weight, whereas other previously reported risk factors such as male sex and certain comorbidities were not observed in our cohort. Our data provide additional insight into AP-ROP treatment patterns including earlier time of treatment, higher risk for retreatment, and therapy preference for intravitreal anti-VEGF therapy.

Indexed as

AP-ROPA-ROPretinopathy of prematurityrisk factorsROP

Identifiers

PMID41948591
PMCPMC13051386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.