ArticleInternational journal of microbiology2026
Gut Microbiota Diversity and Function in Adults With Type 2 Diabetes, Alzheimer's Disease, and Both Conditions.
Article in International journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Gut Microbiota Diversity and Function in Adults With Type 2 Diabetes, Alzheimer's Disease, and Both Conditions.International journal of microbiology · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Type 2 diabetes mellitus (T2DM) is known to increase the risk of Alzheimer's disease (AD), but the role of the gut microbiota in this relationship is not fully understood. This study investigated the gut microbiota profiles of adults with T2DM, adults with AD, both conditions (AD-T2DM), and healthy controls to identify patterns associated with metabolic and neurodegenerative conditions. Methods: A cross-sectional study was conducted with 148 participants divided into six groups: CTRL < 60 years, CTRL ≥ 60 years, T2DM < 60 years, T2DM ≥ 60 years, AD, and AD-T2DM. Clinical assessments and 16S rRNA gene sequencing of fecal samples were performed to analyze microbial diversity and composition. Results: Compared with controls, older adults with T2DM, AD, and AD-T2DM presented reduced microbial diversity and distinct microbial compositions. Notably, SCFA-producing genera ( Conclusion: This study highlights changes in the microbiota in T2DM and AD-T2DM patients, suggesting that targeting these microbial alterations could offer new prevention strategies for metabolic-neurodegenerative comorbidities. Significance Statement: T2DM and AD share metabolic and inflammatory pathways, yet their combined impact on the gut microbiota remains unexplored. By profiling 148 adults, healthy individuals, those with T2DM, AD, and co-occurring AD-T2DM, using 16S rRNA gene V4 region sequencing, we identified specific dysbiosis in AD-T2DM. Rather than examining T2DM and AD as independent conditions, the present study conceptualizes their coexistence as a metabolic-neurodegenerative interaction state and assesses whether this comorbidity is associated with a distinct gut microbiota composition and predicted functional profile. Therefore, we examine the gut microbiota of adults with AD-T2DM using an age-stratified design in an underrepresented Mexican population, integrating clinical, metabolic, cognitive, taxonomic, and functional data to explore potential mechanisms underlying metabolic-neurodegenerative crosstalk. These findings identify microbial genera that may mediate the "diabeto-neuro" crosstalk, offering novel targets for early intervention and precision microbiota-based therapies to mitigate metabolic-neurodegenerative comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.