ArticleBreast cancer (Dove Medical Press)2026
Prognostic Value of Ki-67 and Progesterone Receptor for Risk Stratification and Outcomes by Adjuvant Chemotherapy in Early Luminal-Type Breast Cancer.
Article in Breast cancer (Dove Medical Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Risk stratification of hormone receptor-positive (HR+)/HER2-negative early breast cancer remains variable across studies. We aimed to develop and validate an immunohistochemistry (IHC)-based stratification framework (PR10/Ki20) and a quantitative risk score (RS), and to explore clinical outcomes according to receipt of adjuvant chemotherapy (CT). Methods: This retrospective study analyzed a discovery cohort (KMTTH, n = 2633) and an external validation cohort (KMUH, n = 1147). Using prespecified cutoffs, patients were categorized into four groups: low risk (LR; PR ≥ 10% and Ki-67 < 20%), moderate risk 1 (MR1; PR < 10% and Ki-67 < 20%), moderate risk 2 (MR2; PR ≥ 10% and Ki-67 ≥ 20%), and high risk (HiR; PR < 10% and Ki-67 ≥ 20%). A quantitative Results: The PR10/Ki20 model demonstrated consistent prognostic performance across cohorts. HiR patients had significantly poorer disease-free survival (DFS) and overall survival (OS), whereas the LR group exhibited favorable outcomes. In the validation cohort, adjuvant CT was associated with improved DFS in the HiR group, whereas no statistically significant association was observed in the LR group. The Conclusion: The PR10/Ki20 framework and the derived
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