Evidence map›Paper›PMID 41948519›Full record

ArticleTherapeutic advances in gastroenterology2026

Efficacy and safety of non-invasive transcutaneous nerve stimulation in patients with irritable bowel syndrome: a systematic review and meta-analysis.

Yanbin Wei, Zihe Shi, Shanshan Wu, Xin Yao

Abstract read
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In one paragraph

Article in Therapeutic advances in gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanbin WeiDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Xicheng District, Beijing, China.ORCID https://orcid.org/0009-0004-0246-4551
Zihe ShiDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Xicheng District, Beijing, China.ORCID https://orcid.org/0009-0009-4717-0473
Shanshan WuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, No. 95 Yongan Road, Xicheng District, Beijing 100050, China.ORCID https://orcid.org/0000-0001-9791-8093
Xin YaoDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, No. 95 Yongan Road, Xicheng District, Beijing 100050, China.ORCID https://orcid.org/0000-0002-4230-5457

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder worldwide, characterized by recurrent abdominal pain and altered bowel habits, which significantly impair quality of life and impose a socioeconomic burden. Traditional pharmacological treatments have limited efficacy and are often associated with side effects, highlighting the need for effective non-pharmacological interventions. Non-invasive transcutaneous nerve stimulation (NITNS) has shown potential in improving IBS symptoms and autonomic function, but systematic evidence is lacking. Objectives: To systematically evaluate the efficacy and safety of NITNS in IBS and explore its potential mechanisms. Design: Systematic review and meta-analysis. Data sources and methods: Randomized controlled trials (RCTs) were identified through Results: Four RCTs, including 170 patients, were analyzed. NITNS significantly reduced IBS-SSS scores ( Conclusion: NITNS is a safe and effective non-pharmacological intervention with potential value in the management of IBS. However, further large-scale, high-quality RCTs are needed to confirm their long-term efficacy and safety. Trial registration: PROSPERO CRD420251157617.

Indexed as

efficacyirritable bowel syndromenon-invasive transcutaneous nerve stimulationsafetysystematic review and meta-analysis

Identifiers

PMID41948519
PMCPMC13051232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.