ArticleFrontiers in oncology2026
PD-1 inhibitor-induced systemic sclerosis with early interstitial lung disease and autoimmune thyroiditis in advanced gastric cancer: a case report and literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immune checkpoint inhibitors (ICIs) have revolutionized anti-tumor therapy, yet their use is increasingly complicated by immune-related adverse events (irAEs). We present a rare case in which sequential administration of two PD-1 inhibitors (ICIs), Camrelizumab and Sintilimab, in combination with conventional chemotherapy led to ICI-related systemic sclerosis (ICI-SSc) with early-stage interstitial lung disease (ILD) and autoimmune thyroiditis (AIT). The clinical presentation also suggested a possible scleroderma overlap syndrome. The underlying pathology is likely linked to widespread immune activation following PD-1 pathway blockade. Early identification of ICI-SSc is crucial. Once the diagnosis is confirmed, the suspected drug should be discontinued immediately, and a personalized treatment plan should be initiated, ideally with consideration of the safety profile of steroid-based regimens. Furthermore, our findings raise important considerations regarding pharmacovigilance in the context of sequential ICIs use.
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