Evidence map›Paper›PMID 41948500›Full record

ArticleFrontiers in oncology2026

Dosimetric comparison of TomoTherapy and non-coplanar VMAT for hippocampal-avoidance prophylactic cranial irradiation.

Young Kyu Lee, Wonjoong Cheon, Yunji Seol, Chan-Beom Park, Geum Seong Cheon, Jin-Ho Song, Ji Hyun Hong, Young Nam Kang, Yeon-Sil Kim, Kyu Hye Choi

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Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Young Kyu LeeDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Wonjoong CheonDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yunji SeolDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Chan-Beom ParkDepartment of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Geum Seong CheonDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jin-Ho SongDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ji Hyun HongDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Young Nam KangDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yeon-Sil KimDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kyu Hye ChoiDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To compare the dosimetric characteristics of non-coplanar volumetric modulated arc therapy (VMAT) and TomoTherapy for hippocampal-avoidance prophylactic cranial irradiation (HA-PCI) in small cell lung cancer (SCLC) patients. Methods: Ten SCLC patients who received HA-PCI were retrospectively analyzed. Two plans were generated as TrueBeam non-coplanar VMAT with four arcs and helical TomoTherapy. The hippocampal avoidance zone used a 3-mm margin, reduced from RTOG 0933's 5-mm specification. Planning target volume of whole brain (PTV_WB) was prescribed 25 Gy in 10 fractions, normalized to D Results: Non-coplanar VMAT achieved significantly lower hippocampal D Conclusions: Non-coplanar VMAT demonstrated superior dosimetric characteristics compared to TomoTherapy for HA-PCI with 3-mm margin, meeting hippocampal constraints while improving target coverage and treatment efficiency. Prospective validation with neurocognitive outcomes is needed.

Indexed as

cognitive function preservationdosimetric comparisonhippocampal avoidancenon-coplanar techniqueprophylactic cranial irradiationsmall cell lung cancerTomoTherapyvolumetric modulated arc therapy

Identifiers

PMID41948500
PMCPMC13050688

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