ArticleBiochemistry research international2026
Causal Effect of Low-Density Lipoprotein Cholesterol on Chronic Kidney Disease: A Mendelian Randomization Study.
Article in Biochemistry research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Causal Effect of Low-Density Lipoprotein Cholesterol on Chronic Kidney Disease: A Mendelian Randomization Study.Biochemistry research international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While dyslipidemia is associated with chronic kidney disease (CKD), conventional observational studies cannot establish causality, and previous Mendelian randomization (MR) findings on low-density lipoprotein cholesterol (LDL-C) and CKD remain inconsistent. Objective: To further investigate the causal relationship between LDL-C and CKD using MR and evaluate its independence. Methods: We employed a two-sample and multivariable MR (MVMR) framework. Initially, two-sample and reverse MR analyses were performed for four lipid traits on CKD using genetic data from the IEU Open GWAS and the UK Biobank separately, with a Bonferroni-corrected significance threshold of Results: Two-sample MR showed a significant causal effect of LDL-C on increased CKD risk (IEU source: OR = 1.13, 95% CI: 1.03-1.23, Conclusion: LDL-C may be an independent risk factor for CKD, the independence of which warrants further validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.