Evidence map›Paper›PMID 41948339›Full record

ArticleFrontiers in immunology2026

PTN/IGF-2 signaling modulates endometrial decidualization and immune cell trafficking to facilitate pregnancy maintenance.

Dezhao Chen, Quanrong Li, Huili Yang, Jiawei Shi, Peifang Chen, Tongfei Wang, Ling Zhou, Weichao Dai, Luo Zheng, Mingqing Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dezhao Chen *Department of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Quanrong Li *Department of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Huili YangDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jiawei ShiDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Peifang ChenDepartment of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Tongfei WangDepartment of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Ling ZhouDepartment of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Weichao DaiDepartment of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Luo ZhengDepartment of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.
Mingqing LiDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jie ZhangDepartment of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Zhenzhen LaiDepartment of Obstetrics and Gynecology, Fujian Medical University Union Hospital, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) are major causes of pathological early pregnancy, yet their mechanisms remain poorly understood. This study aimed to identify shared molecular mediators and their roles in endometrial dysfunction and immune regulation. Methods: Gene expression datasets for RIF and RPL were analyzed for differentially expressed genes (DEGs), functional enrichment, and protein-protein interaction (PPI) networks. Key regulators were identified using CytoHubba and Random Forest, and receiver operating characteristic (ROC) analysis evaluated their diagnostic performance. Endometrial stromal cells (ESCs) from RIF or RPL patients were used for Results: PPI network and machine learning analysis identified PTN as a central hub gene shared by RIF and RPL. ROC curves showed that PTN had the highest diagnostic value among all candidate genes. Immunofluorescence confirmed that PTN is mainly expressed in ESCs and downregulated in RIF and RPL patients. Discussion: The PTN/IGF-2 axis promotes ESC decidualization and a tolerogenic immune microenvironment, supporting endometrial receptivity. Dysregulation of this pathway may underlie pathological pregnancies (including RIF and RPL), highlighting PTN as a potential therapeutic target for early pregnancy loss.

Indexed as

Abortion, HabitualDeciduaEndometriumInsulin-Like Growth Factor IIAnimalsCell MovementEmbryo ImplantationFemaleHumansMicePregnancySignal TransductionStromal CellsIGF2 protein, humanInsulin-Like Growth Factor IIdecidualizationIGF-2immune regulationPTNrecurrent implantation failurerecurrent pregnancy loss

Identifiers

PMID41948339
PMCPMC13050712

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.