Evidence map›Paper›PMID 41948329›Full record

ReviewFrontiers in immunology2026

Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms.

Qian Hu, Jiasheng Wang, Ruiyang Cao, Wenkai Liu, Lifeng Wang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qian HuThe First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.
Jiasheng WangThe First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.
Ruiyang CaoThe First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.
Wenkai LiuThe First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.
Lifeng WangThe First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases are a group of chronic, progressive neurological disorders caused by the degeneration and functional loss of neurons and glial cells, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD). Although numerous treatments are available for these diseases, therapeutic outcomes remain unsatisfactory because of their poorly understood pathogeneses of these diseases. Vagus nerve stimulation (VNS), a noninvasive or minimally invasive neuromodulation technique, has shown significant potential in mitigating neurodegenerative conditions. This review explores the mechanisms of action and clinical applications of VNS in neurodegenerative diseases, providing novel insights for the development of novel treatments.

Indexed as

Neurodegenerative DiseasesVagus Nerve StimulationAnimalsHumansOxidative Stressmitochondrial dysfunctionneurodegenerative diseasesneuroinflammationoxidative stressvagus nerve stimulation

Identifiers

PMID41948329
PMCPMC13050663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.