ArticleCureus2026
A Rare Case of Concurrent Typhlitis and Clostridioides difficile Colitis in an Acute Myeloid Leukemia (AML) Patient Undergoing Chemotherapy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Typhlitis (neutropenic enterocolitis) and Clostridioides difficile infection (CDI) are two separate medical conditions. Typhlitis is the inflammation of the cecum and usually occurs in neutropenic patients. CDI is a life-threatening disease of the digestive tract and affects immunocompromised patients. The challenge is when both conditions occur together, especially in patients with hematological malignancies and immune compromise post-chemotherapy. This report of a rare case aims to highlight the co-occurrence of typhlitis and CDI in a patient on chemotherapy after being diagnosed with acute myeloid leukemia (AML). The challenge addressed by this article is how to manage such complex cases in immunocompromised individuals. We report a case of a 41-year-old woman with a history of AML, who presented with fever, abdominal pain, and watery diarrhea after consolidation chemotherapy. Laboratory test results confirmed thrombocytopenia and severe neutropenia. Computed tomography confirmed typhlitis, while stool polymerase chain reaction was positive for toxigenic
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