ArticleCureus2026
Primary Central Nervous System Lymphoma as a Masquerade of Uveitis: A Case Report of Ocular Involvement.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Primary central nervous system lymphoma (PCNSL) often presents with ocular involvement that mimics benign inflammatory conditions, frequently delaying diagnosis. We report a case of a 41-year-old healthy woman presenting with diminished vision and floaters. Examination revealed panuveitis with characteristic hypopigmented retinal lesions exhibiting a 'leopard-skin' pattern. Despite the absence of systemic symptoms and a vitreous sample of low cellularity, diagnostic pars plana vitrectomy confirmed large B-cell lymphoma via immunophenotyping (CD20, CD79a and PAX5). Subsequent magnetic resonance imaging (MRI) demonstrated a parieto-occipital brain mass. The patient received high-dose methotrexate-based chemotherapy according to the DeAngelis protocol, combined with rituximab, selected to optimise disease control while minimising the neurotoxicity associated with whole-brain radiotherapy. She achieved visual recovery to 6/9 and regression of the central nervous system (CNS) lesion. This case underscores the importance of recognising pathognomonic retinal signs and employing molecular immunophenotyping to enable timely, life-saving, neuro-sparing therapy.
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