ReviewClinical ophthalmology (Auckland, N.Z.)2026
The Efficacy and Safety of Nanoparticle-Based Clobetasol Propionate in Managing the Inflammation and Pain in Post-Operative Cataract Patients: A Systematic Review and Meta-Analysis.
Review in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Nanotechnology-based drug delivery systems are emerging as promising solutions for ocular diseases by improving bioavailability and therapeutic effectiveness. This systematic review and meta-analysis evaluated the efficacy and safety of nanoparticle-based clobetasol propionate (CP) in managing inflammation and pain following cataract surgery. Methods: A comprehensive search across multiple databases identified five randomized controlled trials (RCTs) with a total of 1306 participants. Outcomes measured were anterior chamber cell (ACC) grade, anterior chamber flare (ACF) grade, ocular pain scores, and adverse events. Meta-analysis was conducted using RevMan 5.4.1. Results: Meta-analysis demonstrated significant efficacy of CP in achieving an ACC grade of zero at both 8 days (RR = 2.30, 95% CI [1.81, 2.92], p < 0.00001) and 15 days (RR = 3.06, 95% CI [2.29, 4.09], p < 0.00001), and in reducing ACF grades (RR = 1.87 at day 8; RR = 2.30 at day 15, both p < 0.0001). Pain reduction was significantly superior in the CP group at both intervals (RR = 1.73 day 8; RR = 1.77 day 15, both p < 0.00001). The safety profile of CP showed a marginal trend toward fewer adverse events compared to placebo, but without statistical significance (RR = 0.50, 95% CI [0.24, 1.04], p = 0.06). Conclusion: In summary, nanoparticle-based clobetasol propionate is an effective and well-tolerated drug for managing postoperative inflammation and pain in cataract patients.
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