ArticleFrontiers in microbiology2026
Elevated postoperative IL-1β induces disorder of intestinal microenvironment and alteration of gut microbiota.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The gut microbiota-bile acid axis in liver transplantation: implications for postoperative complications and therapeutic strategies.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Previous research hinted at the importance of postoperative gut dysbiosis prevention, but the mechanisms remained unclear, posing a challenge for prevention and therapy. This study aims to investigate the characteristics of postoperative dysbiosis and the underlying mechanisms. Methods: The clinical cohort investigated the perioperative change of gut microbiota in patients undergoing thoracoscopy and its relationship with peripheral inflammatory indicators. Gut microbiome was characterized by 16S rRNA gene sequencing and Bugbase phenotype analysis. In the laboratory study, a mouse model of surgery/anesthesia stress was established to further investigate the potentially underlying mechanisms. Results: Microbiome analysis revealed a decrease in alpha diversity and a shift from obligate anaerobes to aerobes/facultative anaerobes after thoracoscopy. Postoperative IL-1β was negatively correlated with obligate anaerobe abundance and positively correlated with facultative anaerobe abundance. Higher facultative anaerobe abundance was associated with increased risk of postoperative complications and longer hospital stays. In the mouse model, surgery and rIL-1β intervention mirrored the oxygen phenotype changes in clinical cohort, and the colonic epithelium exhibited decreased ATP levels and hypoxic staining scores, with increased lactic acid. Downregulating postoperative IL-1β with IL-1β siRNA mitigated colonic hypoxic environment impairment and gut microbiota oxygen phenotype changes induced by surgery/anesthesia stress. Conclusion: Postoperative gut dysbiosis involves a phenotypic shift of the gut microbiota from anaerobes toward aerobes and facultative anaerobes. This shift may be driven by an IL-1β-colonic epithelial oxygen metabolism-colonic oxygen environment-gut microbiota regulatory axis, offering potential insights for early risk stratification of severe postoperative complications and strategies to improve postoperative recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.