ArticleInternational journal of dentistry2026
Dose-Dependence Relationship Between Radiotherapy and Oral Mucositis in Patients With Head and Neck Cancer: A Retrospective Study.
Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Dose-Dependence Relationship Between Radiotherapy and Oral Mucositis in Patients With Head and Neck Cancer: A Retrospective Study.International journal of dentistry · 2026Article
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8 authors.
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Abstract
Introduction and Purpose: To evaluate the association between radiotherapy (RT) exposure and the presence and severity of radiation-induced oral mucositis (RIOM) in patients with head and neck cancer (HNC). Methods: This retrospective observational study analyzed medical records of 121 patients with HNC treated with 3D conformal RT at a referral hospital in Brazil (2020-2023). Sociodemographic, clinical, and RT-related variables were collected. RIOM was clinically assessed using World Health Organization (WHO) criteria and analyzed using three approaches: presence of RIOM, overall severity (grades 0-4), and severity among affected patients (grades 1-4). Analyses included descriptive, bivariate, and adjusted multivariable binary and ordinal logistic regression models. Results: RIOM was identified in 51 patients (42.1%). No cases of WHO grade 4 were observed. In multivariable analysis, intraoral tumor (aOR = 9.06; 95% CI: 3.51-23.38; Conclusion: RT exposure and intraoral tumor location were the main factors associated with both the presence and severity of RIOM, highlighting the importance of anatomical site and radiation burden for risk stratification.
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