ArticleOncology letters2026
A rare case of uterine carcinosarcoma in a 21-year-old woman with hereditary breast and ovarian cancer syndrome: A case report.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Uterine carcinosarcoma (UCS) is a rare and aggressive malignancy that typically affects postmenopausal women. Its occurrence in young adults, particularly due to hereditary breast and ovarian cancer syndrome (HBOC), is exceptionally uncommon. The present report describes a case of a 21-year-old woman with persistent uterine bleeding who was found to have a uterine mass with para-aortic and pelvic lymphadenopathy and multiple pulmonary metastases. To control bleeding and obtain a definitive diagnosis, the patient underwent a total hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination revealed International Federation of Gynecology and Obstetrics stage IVB UCS. This manifested as poorly differentiated carcinoma and heterologous sarcomatous components with chondrosarcomatous and rhabdomyosarcomatous differentiation. Comprehensive genomic profiling identified a
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