Evidence map›Paper›PMID 41947888›Full record

ArticleAddiction neuroscience2026

Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose.

Delaney McKinstry, Zhenhao Shi, Astrid P Ramos-Rolón, Jeffrey Phillips, Sandhitsu Das, Xinyi Li, Nathan M Hager, Timothy Pond, Nora D Volkow, Henry R Kranzler and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Opioid-Induced Nodding-Not a Nice Nap.Acta scientific neurology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Delaney McKinstryCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Zhenhao ShiCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Astrid P Ramos-RolónCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jeffrey PhillipsDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sandhitsu DasDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Xinyi LiCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Nathan M HagerCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Timothy PondCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Nora D VolkowLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Henry R KranzlerCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jacob G DubroffDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ilya M NasrallahDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Corinde E WiersCenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Funding

Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD, MACH, ROBERT H · 2019 to 2023
$9.4M
T32 Translational Addiction Research Fellowship ProgramT32DA028874 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Julie A Blendy, Anna Rose Childress · 2010 to 2026
$5.0M
Cross-disciplinary training in translational neuroimaging of ADRDT32AG076411 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHN A DETRE, MURRAY GROSSMAN · 2022 to 2026
$1.5M
Multivariate Modeling of the Neural Mechanisms of Treatment Response in Opioid AddictionK01DA051709 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SHI, ZHENHAO · 2021 to 2025
$916k
NIA NIH HHS T32 AG076411NIDA NIH HHS K01 DA051709NIDA NIH HHS P30 DA046345NIDA NIH HHS T32 DA028874
6 · The paper itself

Abstract

Opioid use disorder (OUD) is associated with high rates of overdose (OD)-related morbidity and mortality. OD can cause hypoxic-ischemic injury to oxygen-sensitive brain regions such as the hippocampus. Post-mortem studies show Alzheimer's disease-like hyperphosphorylated tau pathology in the brains of individuals with OUD. Neurocognitive impairments in individuals with OUD may reflect incipient dementia and contribute to poor clinical outcomes. Alternatively, OUD and OD could be independent risk factors for Alzheimer's disease. To date, no study has evaluated the effects of non-fatal ODs or chronic OUD on hippocampal volume and tau deposition in the human brain

Indexed as

Brain agingEpisodic memoryFentanylMagnetic resonance imagingPositron emission tomography

Identifiers

PMID41947888
PMCPMC13052477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.