ArticleJournal of experimental orthopaedics2026
Quantitative analysis of bony and soft tissue contributions to varus deformity across knee osteoarthritis stages.
Article in Journal of experimental orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Medial meniscus extrusion during gait identifies altered knee mechanical loading in early osteoarthritis of the knee.Journal of experimental orthopaedics · 2026Article
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8 authors.
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Abstract
Purpose: To investigate the relationships among lower limb alignment parameters and quantitatively clarify the stage-dependent contributions of bony morphology and soft tissue laxity to varus deformity across knee osteoarthritis stages. Methods: We analysed 1346 knees of 673 participants in a community-based cohort. Radiographic parameters, including the hip-knee-ankle angle (HKAA), weight-bearing line ratio (WBLR), femorotibial angle (FTA), medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA) and joint line convergence angle, were measured using full-length standing radiographs. Spearman's correlation coefficients and linear regression analyses were performed for the overall cohort and stratified subgroups: early- (Kellgren-Lawrence Grade [KLG] 0-1), progressive- (KLG 2) and end-stage (KLG 3-4). Results: In the overall cohort, the HKAA exhibited robust correlations with WBLR ( Conclusions: While bony deformity is a consistent factor, the contribution of soft tissue laxity (joint line convergence angle) becomes substantial in end-stage osteoarthritis. In end-stage osteoarthritis, the joint line convergence angle is a key alignment determinant. Surgical planning for joint-preserving procedures, including high tibial osteotomy, must account for this quantitative confirmation of stage-dependent differences to prevent reducible soft tissue component overcorrection. Level of Evidence: Level III.
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