ArticleFASEB bioAdvances2026
Pulmonary Endothelial Extracellular Vesicles Preferentially Interact and Are Processed in Pulmonary Endothelial Cells.
Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- From Uptake to Therapeutic Function in Engineered Exosome Delivery Systems.Research (Washington, D.C.) · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs) regulate vascular injury and homeostasis; however, the intracellular mechanisms for the EV effects are unknown. While EV components and functions are well studied, their cellular uptake and intracellular processing remain unclear. Following our previous work on EVs, we investigated EV uptake mechanisms and organelle localization. Pulmonary endothelial-derived EVs showed preferential interaction with pulmonary vessels, particularly injured vessels. Co-culture experiments confirmed endothelial cells as exclusive EV targets via energy-dependent, clathrin-mediated endocytosis. Intracellularly, EVs colocalized with lysosomes and trans-Golgi, suggesting degradation and protein recycling pathways. These findings provide insights into temporal EV uptake dynamics and organelle interactions, establishing a foundation for understanding EV processing and content distribution mechanisms.
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Registered trials
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