Evidence map›Paper›PMID 41947558›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Brain glucose extraction is fixed at 10% despite twofold variability in

Jennifer S Duffy, Hannah G Caldwell, Philip N Ainslie, Travis D Gibbons

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Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jennifer S DuffySchool of Physical Education, Sport & Exercise Sciences, University of Otago, Dunedin, New Zealand.ORCID 0009-0003-1350-7353
Hannah G CaldwellCentre for Heart, Lung and Vascular Health, University of British Columbia-Okanagan Campus, Kelowna, BC, Canada.ORCID 0000-0001-6072-7277
Philip N AinslieCentre for Heart, Lung and Vascular Health, University of British Columbia-Okanagan Campus, Kelowna, BC, Canada.
Travis D GibbonsDepartment of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA.ORCID 0000-0003-3893-9948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This commentary addresses the interpretation by Drs. Nybo and Rasmussen of our recent short report examining the interindividual variability in resting human cerebral blood flow (CBF) and metabolism in 75 otherwise healthy adult volunteers. We contend that the authors have mischaracterized the primary objective of the original short report. The objective was to quantify interindividual variability in resting CBF with oxygen and glucose extraction under resting, unstimulated conditions, rather than intraindividual regulatory responses to acute interventions. We highlight that their considerations raised do not invalidate the principal conclusion that lower resting CBF is associated with reduced aerobic glycolysis, possibly due to a greater compensatory capacity of oxygen relative to glucose extraction.

Indexed as

BrainCerebrovascular CirculationGlucoseAdultGlycolysisHumansOxygenOxygen ConsumptionRestGlucoseOxygenAerobic glycolysisarteriovenouscerebral blood flowcerebral metabolismglucose extractionoxygen extraction

Identifiers

PMID41947558
PMCPMC13061831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.